Effects of 3-Week Total Meal Replacement vs. Typical Food-based Diet on Human Brain Functional Magnetic Resonance Imaging Food-cue Reactivity in People with ObesityEffects of 3-week total meal replacement vs. Typical food-based diet on human brain functional MRI food-cue reactivity and functional connectivity in subjects with obesity

Chanaka Kahathuduwa, Tyler Davis, Michael O'Boyle, Lori Boyd, Shao Hua Chin, Dmitrii Paniukov, Martin Binks

Research output: Contribution to journalArticle

Abstract

Objectives Calorie restriction via total meal replacement (TMR) results in greater reduction of food cravings compared to reduced-calorie typical diet (TD). Direct evidence of the impact of these interventions on human brain fMRI food-cue reactivity (fMRI-FCR) and functional connectivity is absent. We examined the effects of a 3-week 1120 kcal/d TMR intervention as compared to an iso-caloric TD intervention using an fMRI-FCR paradigm. Methods Thirty-two male and female subjects with obesity (19–60 years; 30–39.9 kg/m2) participated in a randomized two-group repeated measures dietary intervention study consisting of 1120 kcal/d from either 1) TMR (shakes), 2) TD (portion control). Pre-intervention and following the 3-week diet fMRI-FCR, functional connectivity, food cravings (Food Craving Inventory) and weight were considered. Results Compared to TD, TMR showed increased fMRI-FCR of the bilateral dorsolateral prefrontal (dlPFC), orbitofrontal, anterior cingulate, primary motor and
Original languageEnglish
Pages (from-to)431-441
JournalAppetite / Elsevier B.V.
DOIs
StatePublished - Sep 25 2017

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