Effects of 3-week total meal replacement vs. typical food-based diet on human brain functional magnetic resonance imaging food-cue reactivity and functional connectivity in people with obesity.

Chanaka N Kahathuduwa; T Davis; M O’Boyle; Lori A Boyd; Shao-Hua Chin; D Paniukov; Martin Binks

doi:10.1016/j.appet.2017.09.025

Effects of 3-week total meal replacement vs. typical food-based diet on human brain functional magnetic resonance imaging food-cue reactivity and functional connectivity in people with obesity.

Chanaka N Kahathuduwa, T Davis, M O’Boyle, Lori A Boyd, Shao-Hua Chin, D Paniukov, Martin Binks

Nutritional Sciences

Research output: Contribution to journal › Article

Abstract

OBJECTIVES: Calorie restriction via total meal replacement (TMR) results in greater reduction of food cravings compared to reduced-calorie typical diet (TD). Direct evidence of the impact of these interventions on human brain fMRI food-cue reactivity (fMRI-FCR) and functional connectivity is absent. We examined the effects of a 3-week 1120 kcal/d TMR intervention as compared to an iso-caloric TD intervention using an fMRI-FCR paradigm. METHODS: Thirty-two male and female subjects with obesity (19-60 years; 30-39.9 kg/m2) participated in a randomized two-group repeated measures dietary intervention study consisting of 1120 kcal/d from either 1) TMR (shakes), 2) TD (portion control). Pre-intervention and following the 3-week diet fMRI-FCR, functional connectivity, food cravings (Food Craving Inventory) and weight were considered. RESULTS: Compared to TD, TMR showed increased fMRI-FCR of the bilateral dorsolateral prefrontal (dlPFC), orbitofrontal, anterior cingulate, primary mot

Original language	English
Pages (from-to)	431-441
Journal	Appetite / Elsevier
DOIs	https://doi.org/10.1016/j.appet.2017.09.025
State	Published - Sep 25 2017

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Kahathuduwa, C. N., Davis, T., O’Boyle, M., Boyd, L. A., Chin, S-H., Paniukov, D., & Binks, M. (2017). Effects of 3-week total meal replacement vs. typical food-based diet on human brain functional magnetic resonance imaging food-cue reactivity and functional connectivity in people with obesity. Appetite / Elsevier, 431-441. https://doi.org/10.1016/j.appet.2017.09.025

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abstract = "OBJECTIVES: Calorie restriction via total meal replacement (TMR) results in greater reduction of food cravings compared to reduced-calorie typical diet (TD). Direct evidence of the impact of these interventions on human brain fMRI food-cue reactivity (fMRI-FCR) and functional connectivity is absent. We examined the effects of a 3-week 1120 kcal/d TMR intervention as compared to an iso-caloric TD intervention using an fMRI-FCR paradigm. METHODS: Thirty-two male and female subjects with obesity (19-60 years; 30-39.9 kg/m2) participated in a randomized two-group repeated measures dietary intervention study consisting of 1120 kcal/d from either 1) TMR (shakes), 2) TD (portion control). Pre-intervention and following the 3-week diet fMRI-FCR, functional connectivity, food cravings (Food Craving Inventory) and weight were considered. RESULTS: Compared to TD, TMR showed increased fMRI-FCR of the bilateral dorsolateral prefrontal (dlPFC), orbitofrontal, anterior cingulate, primary mot",

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Effects of 3-week total meal replacement vs. typical food-based diet on human brain functional magnetic resonance imaging food-cue reactivity and functional connectivity in people with obesity. / Kahathuduwa, Chanaka N; Davis, T; O’Boyle, M; Boyd, Lori A; Chin, Shao-Hua; Paniukov, D; Binks, Martin.

In: Appetite / Elsevier, 25.09.2017, p. 431-441.

Research output: Contribution to journal › Article

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AU - Kahathuduwa, Chanaka N

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AU - O’Boyle, M

AU - Boyd, Lori A

AU - Chin, Shao-Hua

AU - Paniukov, D

AU - Binks, Martin

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