TY - JOUR
T1 - Effect of Thermal Gradients Created by Electromagnetic Fields on Cell-Membrane Electroporation Probed by Molecular-Dynamics Simulations
AU - Song, J.
AU - Garner, A. L.
AU - Joshi, R. P.
N1 - Publisher Copyright:
© 2017 American Physical Society.
PY - 2017/2/6
Y1 - 2017/2/6
N2 - The use of nanosecond-duration-pulsed voltages with high-intensity electric fields (∼100 kV/cm) is a promising development with many biomedical applications. Electroporation occurs in this regime, and has been attributed to the high fields. However, here we focus on temperature gradients. Our numerical simulations based on molecular dynamics predict the formation of nanopores and water nanowires, but only in the presence of a temperature gradient. Our results suggest a far greater role of temperature gradients in enhancing biophysical responses, including possible neural stimulation by infrared lasers.
AB - The use of nanosecond-duration-pulsed voltages with high-intensity electric fields (∼100 kV/cm) is a promising development with many biomedical applications. Electroporation occurs in this regime, and has been attributed to the high fields. However, here we focus on temperature gradients. Our numerical simulations based on molecular dynamics predict the formation of nanopores and water nanowires, but only in the presence of a temperature gradient. Our results suggest a far greater role of temperature gradients in enhancing biophysical responses, including possible neural stimulation by infrared lasers.
UR - http://www.scopus.com/inward/record.url?scp=85014615651&partnerID=8YFLogxK
U2 - 10.1103/PhysRevApplied.7.024003
DO - 10.1103/PhysRevApplied.7.024003
M3 - Article
AN - SCOPUS:85014615651
VL - 7
JO - Physical Review Applied
JF - Physical Review Applied
SN - 2331-7019
IS - 2
M1 - 024003
ER -