Abstract
Microcantilever sensors are an offshoot of atomic force microscopy and are useful tools for effectively detecting a target biomolecule. The recognition of the target molecule on the biosensor is based on the physical bending of the microcantilever, which is driven by a specific molecular interaction between the target molecule and the sensor surface. In this study, to enhance the sensitivity of the microcantilever sensor, the sensor surface was modified through a surface conjugation method using self-assembled monolayers (SAMs) and heterobifunctional cross-linkers. After the surface modification of the microcantilever sensor, the sensitivity for L-cysteine was recorded. The detection of L-cysteine was influenced by the active site and the molecular size of the cross-linked compound attached onto the surface of the microcantilever.
Original language | English |
---|---|
Pages (from-to) | 245-248 |
Number of pages | 4 |
Journal | Scanning |
Volume | 29 |
Issue number | 6 |
DOIs | |
State | Published - Nov 2007 |
Keywords
- Conjugation chemistry
- Linker
- Microcantilever
- Self-assembled monolayer
- Surface modification