TY - JOUR
T1 - Effect of phenylbutazone and flunixin meglumine on acute toxic mastitis in dairy cows
AU - Dascanio, J. J.
AU - Mechor, G. D.
AU - Grohn, Y. T.
AU - Kenney, D. G.
AU - Booker, C. A.
AU - Thompson, P.
AU - Chiffelle, C. L.
AU - Musser, J. M.M.
AU - Warnick, L. D.
PY - 1995
Y1 - 1995
N2 - A double-blinded randomized prospective clinical trial was designed to evaluate the effectiveness of flunixin meglumine and phenylbutazone for treatment of acute toxic mastitis in dairy cows. All cows were treated 4 times at 12-hour intervals by intramammary infusion of gentamicin (150 mg). A total of 45 dairy cows with toxic mastitis were randomly assigned to 1 of 3 treatment groups: group 1 (control), saline solution, IV; group 2, 1 g of flunixin meglumine, IV; or group 3, 4 g of phenylbutazone, IV. Physical examination and udder variables were assessed at initial examination and 24 hours later. Milk production was recorded at regular intervals from 1 week before until 10 weeks after development of mastitis. Rear quarters (34/45) were more commonly affected than front quarters. Thirty-five cows returned to the herd, 9 cows were culled, and 1 cow died. There were no significant differences among treatment groups in the need for further treatment or outcome. Klebsiella spp (18/45) and Escherichia coli (16/45) were the most common pathogens isolated by culture of milk from affected quarters. The overall bacteriologic cure rate on days 7 and 14 was 64 and 75%, respectively. At the time of initial examination, cows of the control group had higher rectal temperature than did cows of the flunixin group. At the examination 24 hours later, the rectal temperature of cows in all treatment groups was lower than the temperature at initial examination; at that time (24 hours), however, there were no significant differences in temperature among the treatment groups. Adjusted for stage of lactation, calving season, and parity, mastitic cows, compared with nonmastitic cows from the same herd, had lower milk production in the 10 weeks after development of mastitis, particularly during the week of onset. In repeated measures models, the loss of milk associated with mastitis was not significantly different among the 3 treatment groups.
AB - A double-blinded randomized prospective clinical trial was designed to evaluate the effectiveness of flunixin meglumine and phenylbutazone for treatment of acute toxic mastitis in dairy cows. All cows were treated 4 times at 12-hour intervals by intramammary infusion of gentamicin (150 mg). A total of 45 dairy cows with toxic mastitis were randomly assigned to 1 of 3 treatment groups: group 1 (control), saline solution, IV; group 2, 1 g of flunixin meglumine, IV; or group 3, 4 g of phenylbutazone, IV. Physical examination and udder variables were assessed at initial examination and 24 hours later. Milk production was recorded at regular intervals from 1 week before until 10 weeks after development of mastitis. Rear quarters (34/45) were more commonly affected than front quarters. Thirty-five cows returned to the herd, 9 cows were culled, and 1 cow died. There were no significant differences among treatment groups in the need for further treatment or outcome. Klebsiella spp (18/45) and Escherichia coli (16/45) were the most common pathogens isolated by culture of milk from affected quarters. The overall bacteriologic cure rate on days 7 and 14 was 64 and 75%, respectively. At the time of initial examination, cows of the control group had higher rectal temperature than did cows of the flunixin group. At the examination 24 hours later, the rectal temperature of cows in all treatment groups was lower than the temperature at initial examination; at that time (24 hours), however, there were no significant differences in temperature among the treatment groups. Adjusted for stage of lactation, calving season, and parity, mastitic cows, compared with nonmastitic cows from the same herd, had lower milk production in the 10 weeks after development of mastitis, particularly during the week of onset. In repeated measures models, the loss of milk associated with mastitis was not significantly different among the 3 treatment groups.
UR - http://www.scopus.com/inward/record.url?scp=0029097163&partnerID=8YFLogxK
M3 - Article
C2 - 7486401
AN - SCOPUS:0029097163
SN - 0002-9645
VL - 56
SP - 1213
EP - 1218
JO - American Journal of Veterinary Research
JF - American Journal of Veterinary Research
IS - 9
ER -