TY - JOUR
T1 - Effect of heating on vascular reactivity in rat mesenteric arteries
AU - Massett, Michael P.
AU - Lewis, Stephen J.
AU - Bates, James N.
AU - Kregel, Kevin C.
PY - 1998/8
Y1 - 1998/8
N2 - Vasoconstriction in the viscera is one of the primary cardiovascular adjustments to heating. Local temperature can influence vascular responsiveness to catecholamines and sympathetic nerve activity. Therefore, we hypothesized that heating would after vascular reactivity in rat mesenteric arteries. Concentration-response curves to norepinephrine, phenylephrine, potassium chloride (KCl), calcium, acetylcholine, and sodium nitroprusside were obtained in vascular ring segments from rat mesenteric arteries at 37 and 41°C. In some rings, basal tension increased slightly during heating. Heating to 41°C did not alter the contractile responses to norepinephrine in endothelium-intact or -denuded rings but augmented the responses to KCl and calcium in endothelium-intact rings. The potentiating effect of heating on the responses to KCl and calcium was eliminated after endothelium removal. In contrast, the relaxant responses to acetylcholine and sodium nitroprusside were significantly attenuated at 41°C. Collectively, these results demonstrate that heating alters vascular reactivity in rat mesenteric arteries. Furthermore, these data imply that heating reduces the ability of vascular smooth muscle to relax, possibly due to a decrease in sensitivity to nitric oxide.
AB - Vasoconstriction in the viscera is one of the primary cardiovascular adjustments to heating. Local temperature can influence vascular responsiveness to catecholamines and sympathetic nerve activity. Therefore, we hypothesized that heating would after vascular reactivity in rat mesenteric arteries. Concentration-response curves to norepinephrine, phenylephrine, potassium chloride (KCl), calcium, acetylcholine, and sodium nitroprusside were obtained in vascular ring segments from rat mesenteric arteries at 37 and 41°C. In some rings, basal tension increased slightly during heating. Heating to 41°C did not alter the contractile responses to norepinephrine in endothelium-intact or -denuded rings but augmented the responses to KCl and calcium in endothelium-intact rings. The potentiating effect of heating on the responses to KCl and calcium was eliminated after endothelium removal. In contrast, the relaxant responses to acetylcholine and sodium nitroprusside were significantly attenuated at 41°C. Collectively, these results demonstrate that heating alters vascular reactivity in rat mesenteric arteries. Furthermore, these data imply that heating reduces the ability of vascular smooth muscle to relax, possibly due to a decrease in sensitivity to nitric oxide.
KW - Adrenergic agonists
KW - Endothelium
KW - Hyperthermia
KW - Nitric oxide
KW - Sodium nitroprusside
KW - Vascular smooth muscle
UR - http://www.scopus.com/inward/record.url?scp=0031928357&partnerID=8YFLogxK
U2 - 10.1152/jappl.1998.85.2.701
DO - 10.1152/jappl.1998.85.2.701
M3 - Article
C2 - 9688749
AN - SCOPUS:0031928357
VL - 85
SP - 701
EP - 708
JO - Journal of Applied Physiology
JF - Journal of Applied Physiology
SN - 8750-7587
IS - 2
ER -