Effect of heating on vascular reactivity in rat mesenteric arteries

Michael P. Massett, Stephen J. Lewis, James N. Bates, Kevin C. Kregel

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Vasoconstriction in the viscera is one of the primary cardiovascular adjustments to heating. Local temperature can influence vascular responsiveness to catecholamines and sympathetic nerve activity. Therefore, we hypothesized that heating would after vascular reactivity in rat mesenteric arteries. Concentration-response curves to norepinephrine, phenylephrine, potassium chloride (KCl), calcium, acetylcholine, and sodium nitroprusside were obtained in vascular ring segments from rat mesenteric arteries at 37 and 41°C. In some rings, basal tension increased slightly during heating. Heating to 41°C did not alter the contractile responses to norepinephrine in endothelium-intact or -denuded rings but augmented the responses to KCl and calcium in endothelium-intact rings. The potentiating effect of heating on the responses to KCl and calcium was eliminated after endothelium removal. In contrast, the relaxant responses to acetylcholine and sodium nitroprusside were significantly attenuated at 41°C. Collectively, these results demonstrate that heating alters vascular reactivity in rat mesenteric arteries. Furthermore, these data imply that heating reduces the ability of vascular smooth muscle to relax, possibly due to a decrease in sensitivity to nitric oxide.

Original languageEnglish
Pages (from-to)701-708
Number of pages8
JournalJournal of Applied Physiology
Issue number2
StatePublished - Aug 1998


  • Adrenergic agonists
  • Endothelium
  • Hyperthermia
  • Nitric oxide
  • Sodium nitroprusside
  • Vascular smooth muscle


Dive into the research topics of 'Effect of heating on vascular reactivity in rat mesenteric arteries'. Together they form a unique fingerprint.

Cite this