TY - JOUR
T1 - Effect of green tea and Tai Chi on bone health in postmenopausal osteopenic women
T2 - A 6-month randomized placebo-controlled trial
AU - Shen, C. L.
AU - Chyu, M. C.
AU - Yeh, J. K.
AU - Zhang, Y.
AU - Pence, B. C.
AU - Felton, C. K.
AU - Brismée, J. M.
AU - Arjmandi, B. H.
AU - Doctolero, S.
AU - Wang, J. S.
N1 - Funding Information:
This study was supported by the National Center for Complementary and Alternative Medicine (NCCAM) of the National Institutes of Health under grant 1R21AT003735-01A1. The contents of this manuscript are solely the responsibility of the authors and do not necessarily represent the official views of the NCCAM or the National Institutes of Health. We gratefully acknowledge the study participants; without them, this study would not have been possible. We would like to thank Dr. Jay Magaziner (University of Maryland, MD) for their advice. We also thank Mary J. Flores, Raul Y. Dagda, and Marisela Dagda for their assistance in data collection. Clinical trial number: NCT00625391.
PY - 2012/5
Y1 - 2012/5
N2 - Summary Postmenopausal women with osteopenia received green tea polyphenols (GTP) SUPPL.ement and/or Tai Chi exercise for 6 months. Bone turnover biomarkers, calcium metabolism, and muscle strength were measured. This study showed that GTP SUPPL.ementation and Tai Chi exercise increased bone formation biomarkers and improved bone turnover rate. Tai Chi exercise increased serum parathyroid hormone. GTP SUPPL.ementation, Tai Chi exercise, and the combination of the two all improved muscle strength in postmenopausal women with osteopenia. Introduction This study evaluated the effect of GTP SUPPL.ementation and Tai Chi (TC) exercise on serum markers of bone turnover (bone-specific alkaline phosphatase, BAP, and tartrate-resistant acid phosphatase, TRAP), calcium metabolism, and muscle strength in postmenopausal osteopenic women. Methods One hundred and seventy-one postmenopausal osteopenic women were randomly assigned to four groups: (1) placebo (500 mg starch/day), (2) GTP (500 mg GTP/day), (3) placebo + TC (placebo plus TC training at 60 min/session, three sessions/week), and (4) GTP + TC (GTP plus TC training). Overnight fasting blood and urine samples were collected at baseline, 1, 3, and 6 months for biomarker analyses. Muscle strength was evaluated at baseline, 3, and 6 months. One hundred and fifty subjects completed the 6-month study. Results Significant increases in BAP level due to GTP intake (at 1 month) and TC (at 3 months) were observed. Significant increases in the change of BAP/TRAP ratio due to GTP (at 3 months) and TC (at 6 months) were also observed. Significant main effect of TC on the elevation in serum parathyroid hormone level was observed at 1 and 3 months. At 6 months, muscle strength significantly improved due to GTP, TC, and GTP + TC interventions. Neither GTP nor TC affected serum TRAP, serum and urinary calcium, and inorganic phosphate. Conclusion In summary, GTP SUPPL.ementation and TC exercise increased BAP and improved BAP/TRAP ratio. TC exercise increased serum parathyroid hormone. GTP SUPPL.ementation, TC exercise, and the combination of the two all improved muscle strength in postmenopausal women with osteopenia.
AB - Summary Postmenopausal women with osteopenia received green tea polyphenols (GTP) SUPPL.ement and/or Tai Chi exercise for 6 months. Bone turnover biomarkers, calcium metabolism, and muscle strength were measured. This study showed that GTP SUPPL.ementation and Tai Chi exercise increased bone formation biomarkers and improved bone turnover rate. Tai Chi exercise increased serum parathyroid hormone. GTP SUPPL.ementation, Tai Chi exercise, and the combination of the two all improved muscle strength in postmenopausal women with osteopenia. Introduction This study evaluated the effect of GTP SUPPL.ementation and Tai Chi (TC) exercise on serum markers of bone turnover (bone-specific alkaline phosphatase, BAP, and tartrate-resistant acid phosphatase, TRAP), calcium metabolism, and muscle strength in postmenopausal osteopenic women. Methods One hundred and seventy-one postmenopausal osteopenic women were randomly assigned to four groups: (1) placebo (500 mg starch/day), (2) GTP (500 mg GTP/day), (3) placebo + TC (placebo plus TC training at 60 min/session, three sessions/week), and (4) GTP + TC (GTP plus TC training). Overnight fasting blood and urine samples were collected at baseline, 1, 3, and 6 months for biomarker analyses. Muscle strength was evaluated at baseline, 3, and 6 months. One hundred and fifty subjects completed the 6-month study. Results Significant increases in BAP level due to GTP intake (at 1 month) and TC (at 3 months) were observed. Significant increases in the change of BAP/TRAP ratio due to GTP (at 3 months) and TC (at 6 months) were also observed. Significant main effect of TC on the elevation in serum parathyroid hormone level was observed at 1 and 3 months. At 6 months, muscle strength significantly improved due to GTP, TC, and GTP + TC interventions. Neither GTP nor TC affected serum TRAP, serum and urinary calcium, and inorganic phosphate. Conclusion In summary, GTP SUPPL.ementation and TC exercise increased BAP and improved BAP/TRAP ratio. TC exercise increased serum parathyroid hormone. GTP SUPPL.ementation, TC exercise, and the combination of the two all improved muscle strength in postmenopausal women with osteopenia.
KW - Bone turnover biomarker
KW - Calcium metabolism
KW - Green tea
KW - Mind-body exercise
KW - Muscle strength
KW - Osteoporosis
KW - Tai Chi
UR - http://www.scopus.com/inward/record.url?scp=84863615099&partnerID=8YFLogxK
U2 - 10.1007/s00198-011-1731-x
DO - 10.1007/s00198-011-1731-x
M3 - Article
C2 - 21766228
AN - SCOPUS:84863615099
VL - 23
SP - 1541
EP - 1552
JO - Osteoporosis International
JF - Osteoporosis International
SN - 0937-941X
IS - 5
ER -