TY - JOUR
T1 - Effect of cycling in the heat for 164 km on procoagulant and fibrinolytic parameters
AU - Kupchak, Brian R.
AU - McKenzie, Amy L.
AU - Luk, Hui Ying
AU - Saenz, Cathy
AU - Kunces, Laura J.
AU - Ellis, Lindsay A.
AU - Vingren, Jakob L.
AU - Lee, Elaine C.
AU - Ballard, Kevin D.
AU - Johnson, Evan C.
AU - Kavouras, Stavros A.
AU - Ganio, Matthew S.
AU - Wingo, Jonathon E.
AU - Williamson, Keith H.
AU - Armstrong, Lawrence E.
N1 - Funding Information:
The authors gratefully acknowledge the expertise Keith H Williamson, MD (medical director) for his expertise and the HHH Expo committee for the use of facilities in the Wichita Falls Multi Purpose Event Center. This research study was not funded by external sources; all funds were internal to the University of Connecticut or University of North Texas.
Publisher Copyright:
© 2015, Springer-Verlag Berlin Heidelberg.
PY - 2015/6/1
Y1 - 2015/6/1
N2 - Results: Compared to PRE, increases (p < 0.001) were observed at IP for platelets (39 %), vWF:Ag (65 %), PTF 1 + 2 (47 %), TAT (81 %), tPA Ag (231 %), PAI-1 Ag (148 %), and D-Dimer (54 %). PRE PAI-1 Ag concentrations were directly related to BMI and waist circumference (p < 0.05). D-Dimer concentrations at IP correlated positively with age (p < 0.05).Purpose: We assessed the impact of completing the Hotter’n Hell Hundred (HHH), an annual 164 km road cycling event performed in a hot environment, on hemostatic balance in men.Methods: Sixteen men who completed the ride in <6 h were included in this study. Plasma samples were collected on that morning of the ride (PRE) and immediately on the completion of the ride (IP). Primary hemostasis was assessed by platelet count and von Willebrand factor antigen (vWF:Ag). Coagulation was assessed by measuring prothrombin fragment 1 + 2 (PTF 1 + 2) and thrombin-antithrombin complex (TAT), whereas fibrinolysis was assessed by plasminogen activator inhibitor antigen (PAI-1 Ag), tissue plasminogen activator (tPA Ag), and D-Dimer analyses.Conclusions: Completing the HHH activated the coagulation and fibrinolytic systems in balance. Age was positively correlated with IP D-Dimer concentrations. Additionally, participants displaying a larger BMI and waist circumference exhibited a positive correlation with PRE PAI-1 Ag concentrations.
AB - Results: Compared to PRE, increases (p < 0.001) were observed at IP for platelets (39 %), vWF:Ag (65 %), PTF 1 + 2 (47 %), TAT (81 %), tPA Ag (231 %), PAI-1 Ag (148 %), and D-Dimer (54 %). PRE PAI-1 Ag concentrations were directly related to BMI and waist circumference (p < 0.05). D-Dimer concentrations at IP correlated positively with age (p < 0.05).Purpose: We assessed the impact of completing the Hotter’n Hell Hundred (HHH), an annual 164 km road cycling event performed in a hot environment, on hemostatic balance in men.Methods: Sixteen men who completed the ride in <6 h were included in this study. Plasma samples were collected on that morning of the ride (PRE) and immediately on the completion of the ride (IP). Primary hemostasis was assessed by platelet count and von Willebrand factor antigen (vWF:Ag). Coagulation was assessed by measuring prothrombin fragment 1 + 2 (PTF 1 + 2) and thrombin-antithrombin complex (TAT), whereas fibrinolysis was assessed by plasminogen activator inhibitor antigen (PAI-1 Ag), tissue plasminogen activator (tPA Ag), and D-Dimer analyses.Conclusions: Completing the HHH activated the coagulation and fibrinolytic systems in balance. Age was positively correlated with IP D-Dimer concentrations. Additionally, participants displaying a larger BMI and waist circumference exhibited a positive correlation with PRE PAI-1 Ag concentrations.
KW - Coagulation
KW - Cycling
KW - Fibrinolysis
KW - Heat stress
UR - http://www.scopus.com/inward/record.url?scp=84939977490&partnerID=8YFLogxK
U2 - 10.1007/s00421-015-3107-y
DO - 10.1007/s00421-015-3107-y
M3 - Article
C2 - 25603777
AN - SCOPUS:84939977490
SN - 1439-6319
VL - 115
SP - 1295
EP - 1303
JO - European Journal of Applied Physiology
JF - European Journal of Applied Physiology
IS - 6
ER -