Effect of cycling in the heat for 164 km on procoagulant and fibrinolytic parameters

Brian R. Kupchak, Amy L. McKenzie, Hui Ying Luk, Cathy Saenz, Laura J. Kunces, Lindsay A. Ellis, Jakob L. Vingren, Elaine C. Lee, Kevin D. Ballard, Evan C. Johnson, Stavros A. Kavouras, Matthew S. Ganio, Jonathon E. Wingo, Keith H. Williamson, Lawrence E. Armstrong

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Results: Compared to PRE, increases (p < 0.001) were observed at IP for platelets (39 %), vWF:Ag (65 %), PTF 1 + 2 (47 %), TAT (81 %), tPA Ag (231 %), PAI-1 Ag (148 %), and D-Dimer (54 %). PRE PAI-1 Ag concentrations were directly related to BMI and waist circumference (p < 0.05). D-Dimer concentrations at IP correlated positively with age (p < 0.05).

Purpose: We assessed the impact of completing the Hotter’n Hell Hundred (HHH), an annual 164 km road cycling event performed in a hot environment, on hemostatic balance in men.

Methods: Sixteen men who completed the ride in <6 h were included in this study. Plasma samples were collected on that morning of the ride (PRE) and immediately on the completion of the ride (IP). Primary hemostasis was assessed by platelet count and von Willebrand factor antigen (vWF:Ag). Coagulation was assessed by measuring prothrombin fragment 1 + 2 (PTF 1 + 2) and thrombin-antithrombin complex (TAT), whereas fibrinolysis was assessed by plasminogen activator inhibitor antigen (PAI-1 Ag), tissue plasminogen activator (tPA Ag), and D-Dimer analyses.

Conclusions: Completing the HHH activated the coagulation and fibrinolytic systems in balance. Age was positively correlated with IP D-Dimer concentrations. Additionally, participants displaying a larger BMI and waist circumference exhibited a positive correlation with PRE PAI-1 Ag concentrations.

Original languageEnglish
Pages (from-to)1295-1303
Number of pages9
JournalEuropean journal of applied physiology
Issue number6
StatePublished - Jun 1 2015


  • Coagulation
  • Cycling
  • Fibrinolysis
  • Heat stress


Dive into the research topics of 'Effect of cycling in the heat for 164 km on procoagulant and fibrinolytic parameters'. Together they form a unique fingerprint.

Cite this