TY - JOUR
T1 - Effect of air pockets in drug delivery via jet injections
AU - Rohilla, Pankaj
AU - Khusnatdinov, Emil
AU - Marston, Jeremy
N1 - Funding Information:
This work was financially supported by The National Science Foundation via the award CBET-1749382. We also thank Inovio Pharmaceuticals for providing the jet injector device.
Publisher Copyright:
© 2021 Elsevier B.V.
PY - 2021/6/1
Y1 - 2021/6/1
N2 - Needle-free jet injections are actuated by a pressure impulse that can be delivered by different mechanisms to generate high-speed jets (Vj~O102 m/s). During filling and transportation of disposable cartridges and ampoules, bubbles can form, which can be problematic especially for viscous fluids. Here, we report on the effect of location and size of entrapped air pockets in cartridges used in spring-powered jet injections. As air bubbles pass through the orifice, they undergo depressurization, which results in intermittent atomization and spray formation, temporarily increasing the jet dispersion. Atomization and dispersion of the jet can lead to product loss during an injection. We find that the effect of bubble location on the jet exit speed, delivery efficiency, and the projected area of the blebs formed after the injection was statistically significant (p<0.05). The findings of this study have implications for the development of pre-filled cartridges for jet injection applications.
AB - Needle-free jet injections are actuated by a pressure impulse that can be delivered by different mechanisms to generate high-speed jets (Vj~O102 m/s). During filling and transportation of disposable cartridges and ampoules, bubbles can form, which can be problematic especially for viscous fluids. Here, we report on the effect of location and size of entrapped air pockets in cartridges used in spring-powered jet injections. As air bubbles pass through the orifice, they undergo depressurization, which results in intermittent atomization and spray formation, temporarily increasing the jet dispersion. Atomization and dispersion of the jet can lead to product loss during an injection. We find that the effect of bubble location on the jet exit speed, delivery efficiency, and the projected area of the blebs formed after the injection was statistically significant (p<0.05). The findings of this study have implications for the development of pre-filled cartridges for jet injection applications.
KW - Bubble
KW - Injector
KW - Intradermal
KW - Jet
KW - Viscosity
UR - http://www.scopus.com/inward/record.url?scp=85105476422&partnerID=8YFLogxK
U2 - 10.1016/j.ijpharm.2021.120547
DO - 10.1016/j.ijpharm.2021.120547
M3 - Article
C2 - 33831488
AN - SCOPUS:85105476422
VL - 602
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
SN - 0378-5173
M1 - 120547
ER -