Early iron deficiency enhances stimulus-response learning of adult rats in the context of competing spatial information

Adam T. Schmidt, Guillermo C. Alvarez, William M. Grove, Raghavendra Rao, Michael K. Georgieff

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Iron deficiency early in life results in neurocognitive deficits that persist into adulthood despite iron treatment. The hippocampus is particularly vulnerable to iron deficiency during the fetal and neonatal periods as evidenced by poorer hippocampus-mediated spatial recognition learning. However, the extent to which early iron deficiency alters interactions between hippocampus-based and extra-hippocampus based learning systems remains undetermined. The present study used an ambiguous maze-learning task to examine the learning process in iron sufficient young adult rats that had recovered from iron deficiency in the fetal and neonatal period. Animals were presented with a stimulus response-learning task in the context of spatial information; a procedure designed to elicit competition between dorsal striatum- and hippocampus-based systems respectively. Formerly iron deficient adult rats showed enhanced stimulus-response learning in the context of competing spatial/distal cue information, a finding suggestive of reduced hippocampal functional influence. The study provides evidence that early iron deficiency alters how different learning systems develop and ultimately interact in adulthood. The potential unbalancing of activity among major memory systems during early life has been postulated by others as a relevant factor underlying the developmental origins of certain psychiatric disorders.

Original languageEnglish
Pages (from-to)174-180
Number of pages7
JournalDevelopmental Cognitive Neuroscience
Issue number1
StatePublished - Jan 2012


  • Behavior
  • Hippocampus
  • Iron deficiency
  • Rat
  • Stimulus response learning
  • Striatum


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