n this paper, a previously developed 2-dimensional disease model is studied, which can be used for both epidemiologic modeling and in-host disease modeling. The main attention of this paper is focused on various dynamical behaviors of the system, including Hopf and generalized Hopf bifurcations which yield bistability and tristability, Bogdanov–Takens bifurcation, and homoclinic bifurcation. It is shown that the Bogdanov–Takens bifurcation and homoclinic bifurcation provide a new mechanism for generating disease recurrence, that is, cycles of remission and relapse such as the viral blips observed in HIV infection.
|Journal||Communications in Nonlinear Science and Numerical Simulation|
|State||Published - Aug 2016|