Dynamic reoptimization of a fed-batch fermentor

Mahesh S. Iyer; Theodore F. Wiesner; R. Russell Rhinehart

doi:10.1002/(SICI)1097-0290(19990405)63:1<10::AID-BIT2>3.0.CO;2-C

Dynamic reoptimization of a fed-batch fermentor

Mahesh S. Iyer, Theodore F. Wiesner, R. Russell Rhinehart

Chemical Engineering

Research output: Contribution to journal › Article

15 Scopus citations

Abstract

Traditionally, fed-batch biochemical process optimization and control use complicated models and off-line optimizers with no on-line model adaptation and re-optimization. This work demonstrates the applicability, effectiveness, and economic potential, of a simple phenomenological model for modeling, and a novel optimizer for on-line re-optimization and control of an aerobic fed-batch fermentor.

Original language	English
Pages (from-to)	10-21
Number of pages	12
Journal	Biotechnology and Bioengineering
Volume	63
Issue number	1
DOIs	https://doi.org/10.1002/(SICI)1097-0290(19990405)63:1<10::AID-BIT2>3.0.CO;2-C
State	Published - Apr 5 1999

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Keywords

Dynamic re-optimization
Fed-batch fermentor
Model re- parametrization
Process-model mismatch

Cite this

Iyer, M. S., Wiesner, T. F., & Rhinehart, R. R. (1999). Dynamic reoptimization of a fed-batch fermentor. Biotechnology and Bioengineering, 63(1), 10-21. https://doi.org/10.1002/(SICI)1097-0290(19990405)63:1<10::AID-BIT2>3.0.CO;2-C

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Access to Document

10.1002/(SICI)1097-0290(19990405)63:1<10::AID-BIT2>3.0.CO;2-C

Link to publication in Scopus