Dynamic reoptimization of a fed-batch fermentor

Mahesh S. Iyer, Theodore F. Wiesner, R. Russell Rhinehart

Research output: Contribution to journalArticle

15 Scopus citations


Traditionally, fed-batch biochemical process optimization and control use complicated models and off-line optimizers with no on-line model adaptation and re-optimization. This work demonstrates the applicability, effectiveness, and economic potential, of a simple phenomenological model for modeling, and a novel optimizer for on-line re-optimization and control of an aerobic fed-batch fermentor.

Original languageEnglish
Pages (from-to)10-21
Number of pages12
JournalBiotechnology and Bioengineering
Issue number1
StatePublished - Apr 5 1999



  • Dynamic re-optimization
  • Fed-batch fermentor
  • Model re- parametrization
  • Process-model mismatch

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