Dual hepatocyte-targeting fluorescent probe with high sensitivity to tumorous pH: Precise detection of hepatocellular carcinoma cells

Yamin Zhang, Zhenjie Li, Haibo Ge, Xueyan Zhu, Zhuang Zhao, Zhong quan Qi, Mian Wang, Jianyi Wang

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

A new dual hepatocyte-targeting fluorescent probe HPL-1, which can precisely distinguish tumorous pH from physiological pH, was developed. The OFF-ON switch of HPL-1 can be triggered via pH-induced structural change of the lactam group of the rhodamine moiety from closed-ring to open-ring. Our results showed that the phosphate group of HPL-1 is beneficial to its accumulation in liver cells, and combination of the phosphate and galactose units could synergistically increase the hepatocyte-targeting capacity. HPL-1 could selectively distinguish hepatoma cells from other tissue cells, and precisely distinguish cancerous liver cells from normal liver cells. Compared with other reported probes, HPL-1 not only enable a simple and convenient detection method, but also has good hepatocyte-targeting capacity and precise recognition capacity of tumors under weak acid micro-environment, which opens new avenues for precise diagnosis and treatment of hepatocellular carcinoma.

Original languageEnglish
Pages (from-to)584-589
Number of pages6
JournalSensors and Actuators, B: Chemical
Volume285
DOIs
StatePublished - Apr 15 2019

Keywords

  • Fluorescent probe
  • Galactose
  • Hepatocyte-targeting
  • Phosphate
  • Tumorous pH

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