Drug Coated Microneedles for Minimally-Invasive Treatment of Oral Carcinomas: Development and In Vitro Evaluation

Yunzhe Ma, Seth Boese, Zhen Luo, N Nitin, Harvinder Gill

Research output: Contribution to journalArticle

Abstract

Treatment of recurring oral cancers is challenging as common surgical approaches are not feasible for these patients. In addition, these patients do not respond well to systemic chemotherapy. Localized intratumoral injection of anti-cancer drugs is considered to be an attractive alternative treatment approach for these patients. However, conventional hypodermic injections result in poor distribution of the drug in the tumor and leakage of the drug from the injection site to systemic circulation, in addition to causing pain to the patient. The objective of this study was to develop coated microneedles as a novel device for direct and minimally invasive intratumoral delivery of anti-cancer drugs. Poly(lactic-co-glycolic) acid (PLGA) nanoparticles encapsulating doxorubicin (DOX) were prepared and coated on inplane (1D) microneedles. Microscopic evaluation of 3D tissue phantoms and porcine cadaver buccal tissues that were treated with 1D microneedle arrays coated with DOX-PLGA nanoparticl
Original languageEnglish
JournalBiomedical Microdevices
DOIs
StatePublished - 2015

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