Domino [3+2+1] heteroannulation for stereoselective synthesis of anti-pyrazolo[3,4-d][1,3]oxazines

Yi Ning, Wei Fan, Wen Juan Hao, Mu Yan Sun, Bo Jiang, Shu Jiang Tu, And Guigen Li

Research output: Contribution to journalArticlepeer-review

Abstract

A novel three-component domino reaction of arylglyoxals with pyrazol-5-amines in HOAc has been developed, providing an efficient and stereoselective access to polysubstituted anti-pyrazolo[3,4-d][l,3]oxazines in a intermolecular manner. Features of this strategy include mild conditions, convenient one-pot operation, and excellent stereoselectivity, which make highly attractive.

Original languageEnglish
Pages (from-to)815-823
Number of pages9
JournalHeterocycles
Volume91
Issue number4
DOIs
StatePublished - 2015

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