Does needle size matter?

Harvinder Gill, M. R. Prausnitz

Research output: Contribution to journalArticlepeer-review


Hypodermic needles are in widespread use, but patients are unhappy with the pain, anxiety, and difficulty of using them. To increase patient acceptance, smaller needle diameters and lower insertion forces have been shown to reduce the frequency of painful injections. Guided by these observations, fine needles and microneedles have been developed to minimize pain and have found the greatest utility for delivery of vaccines and biopharmaceuticals such as insulin. However, pain reduction must be balanced against limitations of injection depth, volume, and formulations introduced by reduced needle dimensions. In some cases, needle-free delivery methods provide useful alternatives.
Original languageEnglish
Pages (from-to)725-9
JournalJ Diabetes Sci Technol
StatePublished - 2007


Dive into the research topics of 'Does needle size matter?'. Together they form a unique fingerprint.

Cite this