Does needle size matter?

Harvinder S. Gill, Mark R. Prausnitz

Research output: Contribution to journalArticlepeer-review

99 Scopus citations


Hypodermic needles are in widespread use, but patients are unhappy with the pain, anxiety, and difficulty of using them. To increase patient acceptance, smaller needle diameters and lower insertion forces have been shown to reduce the frequency of painful injections. Guided by these observations, fine needles and microneedles have been developed to minimize pain and have found the greatest utility for delivery of vaccines and biopharmaceuticals such as insulin. However, pain reduction must be balanced against limitations of injection depth, volume, and formulations introduced by reduced needle dimensions. In some cases, needlefree delivery methods provide useful alternatives.

Original languageEnglish
Pages (from-to)725-729
Number of pages5
JournalJournal of Diabetes Science and Technology
Issue number5
StatePublished - Sep 2007


  • Drug delivery
  • Hypodermic needle
  • Insulin delivery methods
  • Microneedle injection
  • Needle gauge
  • Needle length
  • Pain from needle insertion


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