TY - JOUR
T1 - Does needle size matter?
AU - Gill, Harvinder S.
AU - Prausnitz, Mark R.
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2007/9
Y1 - 2007/9
N2 - Hypodermic needles are in widespread use, but patients are unhappy with the pain, anxiety, and difficulty of using them. To increase patient acceptance, smaller needle diameters and lower insertion forces have been shown to reduce the frequency of painful injections. Guided by these observations, fine needles and microneedles have been developed to minimize pain and have found the greatest utility for delivery of vaccines and biopharmaceuticals such as insulin. However, pain reduction must be balanced against limitations of injection depth, volume, and formulations introduced by reduced needle dimensions. In some cases, needlefree delivery methods provide useful alternatives.
AB - Hypodermic needles are in widespread use, but patients are unhappy with the pain, anxiety, and difficulty of using them. To increase patient acceptance, smaller needle diameters and lower insertion forces have been shown to reduce the frequency of painful injections. Guided by these observations, fine needles and microneedles have been developed to minimize pain and have found the greatest utility for delivery of vaccines and biopharmaceuticals such as insulin. However, pain reduction must be balanced against limitations of injection depth, volume, and formulations introduced by reduced needle dimensions. In some cases, needlefree delivery methods provide useful alternatives.
KW - Drug delivery
KW - Hypodermic needle
KW - Insulin delivery methods
KW - Microneedle injection
KW - Needle gauge
KW - Needle length
KW - Pain from needle insertion
UR - http://www.scopus.com/inward/record.url?scp=78751648781&partnerID=8YFLogxK
U2 - 10.1177/193229680700100517
DO - 10.1177/193229680700100517
M3 - Article
AN - SCOPUS:78751648781
VL - 1
SP - 725
EP - 729
JO - Journal of Diabetes Science and Technology
JF - Journal of Diabetes Science and Technology
SN - 1932-2968
IS - 5
ER -