TY - JOUR
T1 - Does L-citrulline supplementation improve exercise blood flow in older adults?
AU - Gonzales, Joaquin
AU - Raymond, Andrea
AU - Ashley, John
AU - Kim, Youngdeok
PY - 2017/12/1
Y1 - 2017/12/1
N2 - L-citrulline (Cit) increases arginine (Arg), the primary substrate for nitric oxide biosynthesis. We tested the hypothesis that muscle blood flow during exercise would be enhanced by Cit supplementation in older adults. Femoral artery blood flow was measured during calf exercise using Doppler ultrasound, and vascular conductance (FVC) was calculated in 25 older adults (13W, 12M) before and after 14 days of Cit (6 g/day) and placebo (maltodextrin) in a randomized, double-blind, crossover study. Plasma [Arg] and resting blood pressure were also measured before and after each condition. Women and men were analyzed separately due to significant sex-by-condition interactions for the change in exercise blood flow and FVC. Plasma [Arg] was increased by 30% and 35% following Cit (P < 0.01) in women and men, respectively, with no change after placebo. Citrulline lowered diastolic blood pressure in men (75 ± 9 vs. 71 ± 6 mmHg, P = 0.02), but remained unchanged in women. Blood flow and FVC durin
AB - L-citrulline (Cit) increases arginine (Arg), the primary substrate for nitric oxide biosynthesis. We tested the hypothesis that muscle blood flow during exercise would be enhanced by Cit supplementation in older adults. Femoral artery blood flow was measured during calf exercise using Doppler ultrasound, and vascular conductance (FVC) was calculated in 25 older adults (13W, 12M) before and after 14 days of Cit (6 g/day) and placebo (maltodextrin) in a randomized, double-blind, crossover study. Plasma [Arg] and resting blood pressure were also measured before and after each condition. Women and men were analyzed separately due to significant sex-by-condition interactions for the change in exercise blood flow and FVC. Plasma [Arg] was increased by 30% and 35% following Cit (P < 0.01) in women and men, respectively, with no change after placebo. Citrulline lowered diastolic blood pressure in men (75 ± 9 vs. 71 ± 6 mmHg, P = 0.02), but remained unchanged in women. Blood flow and FVC durin
M3 - Article
SP - 1661
EP - 1671
JO - Experimental Physiology
JF - Experimental Physiology
ER -