TY - JOUR
T1 - Dnases in health and disease
AU - Keyel, Peter A.
N1 - Funding Information:
I apologize to authors whose work was omitted inadvertently or due to space constraints. PAK is supported by the American Heart Association [grant number 16SDG30200001], The CH Foundation and Texas Tech University [start-up funding]. The funders had no role in the design, analysis or interpretation of data; in the writing of the review; nor in the decision to submit the article for publication. The author declares no conflict of interest.
Publisher Copyright:
© 2017 The Authors
PY - 2017/9/1
Y1 - 2017/9/1
N2 - DNA degradation is critical to healthy organism development and survival. Two nuclease families that play key roles in development and in disease are the Dnase1 and Dnase2 families. While these two families were initially characterized by biochemical function, it is now clear that multiple enzymes in each family perform similar, non-redundant roles in many different tissues. Most Dnase1 and Dnase2 family members are poorly characterized, yet their elimination can lead to a wide range of diseases, including lethal anemia, parakeratosis, cataracts and systemic lupus erythematosus. Therefore, understanding these enzyme families represents a critical field of emerging research. This review explores what is currently known about Dnase1 and Dnase2 family members, highlighting important questions about the structure and function of family members, and how their absence translates to disease.
AB - DNA degradation is critical to healthy organism development and survival. Two nuclease families that play key roles in development and in disease are the Dnase1 and Dnase2 families. While these two families were initially characterized by biochemical function, it is now clear that multiple enzymes in each family perform similar, non-redundant roles in many different tissues. Most Dnase1 and Dnase2 family members are poorly characterized, yet their elimination can lead to a wide range of diseases, including lethal anemia, parakeratosis, cataracts and systemic lupus erythematosus. Therefore, understanding these enzyme families represents a critical field of emerging research. This review explores what is currently known about Dnase1 and Dnase2 family members, highlighting important questions about the structure and function of family members, and how their absence translates to disease.
KW - Apoptosis
KW - Development
KW - Lupus
KW - Nuclease
UR - http://www.scopus.com/inward/record.url?scp=85021387912&partnerID=8YFLogxK
U2 - 10.1016/j.ydbio.2017.06.028
DO - 10.1016/j.ydbio.2017.06.028
M3 - Review article
C2 - 28666955
AN - SCOPUS:85021387912
VL - 429
SP - 1
EP - 11
JO - Developmental Biology
JF - Developmental Biology
SN - 0012-1606
IS - 1
ER -