TY - JOUR
T1 - DNA methylation and polyamines in regulation of development of the fungus Mucor rouxii
AU - Cano, C.
AU - Herrera-Estrella, L.
AU - Ruiz-Herrera, J.
PY - 1988
Y1 - 1988
N2 - DNA from intact or spherically growing spores of Mucor rouxii is highly methylated, whereas DNA from germlings has low levels of methylation. DNA from spores incubated with hydroxyurea or 1,4-diaminobutanone is also highly methylated. The reversal of the effect of 1,4-diaminobutanone by azacytidine correlated with DNA hypomethylation. These data suggest that the change in growth pattern from spherical to polarized correlates with the degree of DNA methylation and that this, in turn, may be controlled by polyamine levels.
AB - DNA from intact or spherically growing spores of Mucor rouxii is highly methylated, whereas DNA from germlings has low levels of methylation. DNA from spores incubated with hydroxyurea or 1,4-diaminobutanone is also highly methylated. The reversal of the effect of 1,4-diaminobutanone by azacytidine correlated with DNA hypomethylation. These data suggest that the change in growth pattern from spherical to polarized correlates with the degree of DNA methylation and that this, in turn, may be controlled by polyamine levels.
UR - http://www.scopus.com/inward/record.url?scp=0024211086&partnerID=8YFLogxK
U2 - 10.1128/jb.170.12.5946-5948.1988
DO - 10.1128/jb.170.12.5946-5948.1988
M3 - Article
C2 - 2461361
AN - SCOPUS:0024211086
SN - 0021-9193
VL - 170
SP - 5946
EP - 5948
JO - Journal of Bacteriology
JF - Journal of Bacteriology
IS - 12
ER -