DNA demethylases are required for myo-inositol-mediated mutualism between plants and beneficial rhizobacteria

Juan I. Vílchez, Yu Yang, Danxia He, Hailing Zi, Li Peng, Suhui Lv, Richa Kaushal, Wei Wang, Weichang Huang, Renyi Liu, Zhaobo Lang, Daisuke Miki, Kai Tang, Paul W. Paré, Chun Peng Song, Jian Kang Zhu, Huiming Zhang

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Root-associated soil bacteria can strongly influence plant fitness. DNA methylation is an epigenetic mark important to many fundamental biological processes; however, its roles in plant interactions with beneficial microbes remain elusive. Here, we report that active DNA demethylation in Arabidopsis controls root secretion of myo-inositol and consequently plant growth promotion triggered by Bacillus megaterium strain YC4. Root-secreted myo-inositol is critical for YC4 colonization and preferentially attracts B. megaterium among the examined bacteria species. Active DNA demethylation antagonizes RNA-directed DNA methylation in controlling myo-inositol homeostasis. Importantly, we demonstrate that active DNA demethylation controls myo-inositol-mediated mutualism between YC4 and Solanum lycopersicum, thus suggesting a conserved nature of this epigenetic regulatory mechanism.

Original languageEnglish
Pages (from-to)983-995
Number of pages13
JournalNature Plants
Volume6
Issue number8
DOIs
StatePublished - Aug 1 2020

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