TY - JOUR
T1 - Discriminative stimulus properties of amphetamine and other stimulants in lead-exposed and normal rats
AU - Rosen, Jeffrey B.
AU - Young, Alice M.
AU - Beuthin, Frederic C.
AU - Louis-Ferdinand, Robert T.
N1 - Funding Information:
1Supported by USPHS grant RR-08167-07, a WSU Faculty Research Award, and a WSU Neurosoence Program Small Grant to A M Y and by USPHS grant ES-01638 to R T L During the preparation of this report J B R was supported by a WSU Neurosctence Program fellowship A prehmmary report of these data was presented to the Psychopharmacology Division, American Psychological Association, Washington, DC, 1982 -'Requests for reprints should be addressed to Dr Ahce Young, Department of Psychology, Wayne State Umverslty, 71 W Warren, Detroit, MI 48202
PY - 1986/2
Y1 - 1986/2
N2 - The present study examined the discriminative stimulus properties of amphetamine (AMP) at progressively lower doses in lead-exposed and normal rats. In addition, generalization gradients of AMP, apomorphine, methylphenidate, and caffeine to both high and low training doses of AMP were determined in these rats. Under the high AMP training dose condition (1.0 mg/kg, IP) generalization gradients of AMP were similar for lead-exposed and control rats. When the training doses were progressively lowered, the lead-exposed rats tended to require a higher range of AMP doses (0.24-0.49 mg/kg) than did control rats (0.18-0.32 mg/kg) to maintain discriminative control. In parallel with this, the minimal discriminable doses tended to be higher for lead-exposed rats than for control rats. Methylphenidate generalization gradients were different for lead-exposed and control rats under the high AMP training condition but became similar under the low AMP training condition. No differences attributable to training dose or lead exposure were evident for apomorphine or caffeine.
AB - The present study examined the discriminative stimulus properties of amphetamine (AMP) at progressively lower doses in lead-exposed and normal rats. In addition, generalization gradients of AMP, apomorphine, methylphenidate, and caffeine to both high and low training doses of AMP were determined in these rats. Under the high AMP training dose condition (1.0 mg/kg, IP) generalization gradients of AMP were similar for lead-exposed and control rats. When the training doses were progressively lowered, the lead-exposed rats tended to require a higher range of AMP doses (0.24-0.49 mg/kg) than did control rats (0.18-0.32 mg/kg) to maintain discriminative control. In parallel with this, the minimal discriminable doses tended to be higher for lead-exposed rats than for control rats. Methylphenidate generalization gradients were different for lead-exposed and control rats under the high AMP training condition but became similar under the low AMP training condition. No differences attributable to training dose or lead exposure were evident for apomorphine or caffeine.
KW - Amphetamine
KW - Apomorphine
KW - Caffeine
KW - Drug discrimination
KW - Lead
KW - Lead exposure
KW - Methylphenidate
UR - http://www.scopus.com/inward/record.url?scp=0022643940&partnerID=8YFLogxK
U2 - 10.1016/0091-3057(86)90340-0
DO - 10.1016/0091-3057(86)90340-0
M3 - Article
C2 - 2869503
AN - SCOPUS:0022643940
SN - 0091-3057
VL - 24
SP - 211
EP - 215
JO - Pharmacology, Biochemistry and Behavior
JF - Pharmacology, Biochemistry and Behavior
IS - 2
ER -