Dimensionality Reduction based Transfer Learning applied to Pharmacogenomics Databases

Saugato Rahman Dhruba, Raziur Rahmanl, Kevin Matlockl, Soupatno Ghosh, Ranadip Pal

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

Recent years have observed a number of Pharmacogenomics databases being published that enable testing of various predictive modeling techniques for personalized therapy applications. However, the consistencies between the databases are usually limited in spite of having significant number of common cell lines and drugs. In this article, we consider the problem of whether we can use the model learned from one secondary database to improve the prediction for the other target database. We illustrate using two pharmacogenomics databases that representing the databases using common basis vectors can improve prediction performance as compared to the naive application of a model trained on one database to another. We also elucidate the robustness of using PCA based basis vectors for scenarios with low correlated input features.

Original languageEnglish
Title of host publication40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages1246-1249
Number of pages4
ISBN (Electronic)9781538636466
DOIs
StatePublished - Oct 26 2018
Event40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018 - Honolulu, United States
Duration: Jul 18 2018Jul 21 2018

Publication series

NameProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
Volume2018-July
ISSN (Print)1557-170X

Conference

Conference40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018
CountryUnited States
CityHonolulu
Period07/18/1807/21/18

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  • Cite this

    Dhruba, S. R., Rahmanl, R., Matlockl, K., Ghosh, S., & Pal, R. (2018). Dimensionality Reduction based Transfer Learning applied to Pharmacogenomics Databases. In 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018 (pp. 1246-1249). [8512457] (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS; Vol. 2018-July). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBC.2018.8512457