We report the first example of difluoroalkylation/C-H annulation cascade reactions of cyclopropyl olefins induced by visible-light photoredox catalysis regioselectively affording partially hydrogenated naphthalenes and quinolines with a variety of difluorinated side chains. The alkylation reagent could be extended to monofluoro and trifluoro reagents, nitrite and malonate. The regioselectivity was investigated by means of density functional theory calculations.
|Journal||Journal of Organic Chemistry|
|State||Published - Oct 2016|