Difluoroalkylation/C-H Annulation Cascade Reaction Induced by Visible-Light Photoredox Catalysis

Jin Li, Jingzhi Chen, Wei Jiao, Guoqiang Wang, Ying Li, Xu Cheng, Guigen Li

Research output: Contribution to journalArticle

Abstract

We report the first example of difluoroalkylation/C-H annulation cascade reactions of cyclopropyl olefins induced by visible-light photoredox catalysis regioselectively affording partially hydrogenated naphthalenes and quinolines with a variety of difluorinated side chains. The alkylation reagent could be extended to monofluoro and trifluoro reagents, nitrite and malonate. The regioselectivity was investigated by means of density functional theory calculations.
Original languageEnglish
Pages (from-to)9992-10001
JournalJournal of Organic Chemistry
StatePublished - Oct 2016

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