Difluoroalkylation/C-H Annulation Cascade Reaction Induced by Visible-Light Photoredox Catalysis

Jin Li, Jingzhi Chen, Wei Jiao, Guoqiang Wang, Ying Li, Xu Cheng, Guigen Li

Research output: Contribution to journalArticlepeer-review

45 Scopus citations


We report the first example of difluoroalkylation/C-H annulation cascade reactions of cyclopropyl olefins induced by visible-light photoredox catalysis regioselectively affording partially hydrogenated naphthalenes and quinolines with a variety of difluorinated side chains. The alkylation reagent could be extended to monofluoro and trifluoro reagents, nitrile and malonate. The regioselectivity was investigated by means of density functional theory calculations.

Original languageEnglish
Pages (from-to)9992-10001
Number of pages10
JournalJournal of Organic Chemistry
Issue number20
StatePublished - Oct 21 2016


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