Abstract
We report the first example of difluoroalkylation/C-H annulation cascade reactions of cyclopropyl olefins induced by visible-light photoredox catalysis regioselectively affording partially hydrogenated naphthalenes and quinolines with a variety of difluorinated side chains. The alkylation reagent could be extended to monofluoro and trifluoro reagents, nitrile and malonate. The regioselectivity was investigated by means of density functional theory calculations.
| Original language | English |
|---|---|
| Pages (from-to) | 9992-10001 |
| Number of pages | 10 |
| Journal | Journal of Organic Chemistry |
| Volume | 81 |
| Issue number | 20 |
| DOIs | |
| State | Published - Oct 21 2016 |
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Li, J., Chen, J., Jiao, W., Wang, G., Li, Y., Cheng, X., & Li, G. (2016). Difluoroalkylation/C-H Annulation Cascade Reaction Induced by Visible-Light Photoredox Catalysis. Journal of Organic Chemistry, 81(20), 9992-10001. https://doi.org/10.1021/acs.joc.6b01825