Differences in Oocyte Development and Estradiol Sensitivity among Mouse Strains

Melissa E. Pepling, Emily Sundman, Nicole L. Patterson, Grant W. Gephardt, Leonard Medico Jr, Krystal I. Wilson

Research output: Contribution to journalArticlepeer-review


Mouse oocytes develop in clusters of interconnected cells called germline cysts. Shortly after birth, the majority of cysts break apart and primordial follicles form, consisting of one oocyte surrounded by granulosa cells. Concurrently, oocyte number is reduced by two-thirds. Exposure of neonatal females to estrogenic compounds causes multiple oocyte follicles that are likely germline cysts that did not break down. Supporting this idea, estrogen disrupts cyst breakdown and may regulate normal oocyte development. Previously, the CD-1 strain was used to study cyst breakdown and oocyte survival, but it is unknown if there are differences in these processes in other mouse strains. It is also unknown if there are variations in estrogen sensitivity during oocyte development. Here, we examined neonatal oocyte development in FVB, C57BL/6, and F2 hybrid (Oct4-GFP) strains, and compared them with the CD-1 strain. We found variability in oocyte development among the four strains. We also investi
Original languageEnglish
Pages (from-to)349-357
StatePublished - Feb 1 2010


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