Dietary whey and egg proteins interact with inulin fiber to modulate energy balance and gut microbiota in obese rats

B. S. Avirineni, A. Singh, R. C. Zapata, Caleb Phillips, Prasanth Chelikani

Research output: Contribution to journalArticle

Abstract

Diets supplemented with protein and fiber are well known to reduce food intake and weight gain; however, less is known about the combined effects of protein and prebiotic fiber on energy balance and gut microbiota composition. We compared effects of diets containing high egg or whey protein with cellulose or prebiotic (inulin) fiber on energy balance, gut microbiota, hormones, and metabolites. Male obese rats (n=8/group) were allocated to four diets: Egg albumen+Cellulose (EC), Egg albumen+Inulin (EI), Whey protein+Cellulose (WC), and Whey protein+Inulin (WI). Results revealed that diet-induced hypophagia was transient with EC and prolonged with EI and WI, compared to WC. Importantly, CCK-1 receptor antagonist (Devazepide) attenuated the hypophagic effects of EC, EI, and WI. Further, EC, EI and WI decreased respiratory quotient, energy expenditure, weight and adiposity gains, and improved glycemia, relative to WC. Propranolol (beta1-beta2-receptor blocker) attenuated diet-ind
Original languageEnglish
Pages (from-to)108860
JournalDefault journal
StatePublished - 2021

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