Dietary selenium and aniline-induced methemoglobinemia in rats

Miao Lin Hu; Julian E. Spallholz

doi:10.1016/0378-4274(85)90083-9

Dietary selenium and aniline-induced methemoglobinemia in rats

Miao Lin Hu, Julian E. Spallholz

Nutritional Sciences

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Depletion of selenium from rats for 8 weeks decreased blood glutathione peroxidase activity to 5.7% of that in selenium-supplemented (0.5 ppm selenium as Na₂SeO₃) rats. Aniline (60 mg/kg, i.p.) resulted in no significant difference in methemoglobin and blood reduced glutathione (GSH) levels between Se-deficient and Se-supplemented rats. A lowered aniline dose (36 mg/kg, i.p.) also resulted in no difference in methemoglobin levels. The selenium-deficient rat was able to reduce methemoglobin induced by aniline as efficiently as the selenium-sufficient rat.

Original language	English
Pages (from-to)	205-210
Number of pages	6
Journal	Toxicology Letters
Volume	25
Issue number	2
DOIs	https://doi.org/10.1016/0378-4274(85)90083-9
State	Published - May 1985

Keywords

Selenium
analine
anemia
net hemoglobin
oxidation
toxicity

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10.1016/0378-4274(85)90083-9

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title = "Dietary selenium and aniline-induced methemoglobinemia in rats",

abstract = "Depletion of selenium from rats for 8 weeks decreased blood glutathione peroxidase activity to 5.7% of that in selenium-supplemented (0.5 ppm selenium as Na2SeO3) rats. Aniline (60 mg/kg, i.p.) resulted in no significant difference in methemoglobin and blood reduced glutathione (GSH) levels between Se-deficient and Se-supplemented rats. A lowered aniline dose (36 mg/kg, i.p.) also resulted in no difference in methemoglobin levels. The selenium-deficient rat was able to reduce methemoglobin induced by aniline as efficiently as the selenium-sufficient rat.",

keywords = "Selenium, analine, anemia, net hemoglobin, oxidation, toxicity",

author = "Hu, {Miao Lin} and Spallholz, {Julian E.}",

note = "Funding Information: This study was supported by the Kobert A. The authors thank Mr. C. Chung for his process.",

year = "1985",

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T1 - Dietary selenium and aniline-induced methemoglobinemia in rats

AU - Hu, Miao Lin

AU - Spallholz, Julian E.

N1 - Funding Information: This study was supported by the Kobert A. The authors thank Mr. C. Chung for his process.

PY - 1985/5

Y1 - 1985/5

N2 - Depletion of selenium from rats for 8 weeks decreased blood glutathione peroxidase activity to 5.7% of that in selenium-supplemented (0.5 ppm selenium as Na2SeO3) rats. Aniline (60 mg/kg, i.p.) resulted in no significant difference in methemoglobin and blood reduced glutathione (GSH) levels between Se-deficient and Se-supplemented rats. A lowered aniline dose (36 mg/kg, i.p.) also resulted in no difference in methemoglobin levels. The selenium-deficient rat was able to reduce methemoglobin induced by aniline as efficiently as the selenium-sufficient rat.

AB - Depletion of selenium from rats for 8 weeks decreased blood glutathione peroxidase activity to 5.7% of that in selenium-supplemented (0.5 ppm selenium as Na2SeO3) rats. Aniline (60 mg/kg, i.p.) resulted in no significant difference in methemoglobin and blood reduced glutathione (GSH) levels between Se-deficient and Se-supplemented rats. A lowered aniline dose (36 mg/kg, i.p.) also resulted in no difference in methemoglobin levels. The selenium-deficient rat was able to reduce methemoglobin induced by aniline as efficiently as the selenium-sufficient rat.

KW - Selenium

KW - analine

KW - anemia

KW - net hemoglobin

KW - oxidation

KW - toxicity

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ER -

Dietary selenium and aniline-induced methemoglobinemia in rats

Abstract

Keywords

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