Dietary selenium and aniline-induced methemoglobinemia in rats

Miao Lin Hu, Julian E. Spallholz

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Depletion of selenium from rats for 8 weeks decreased blood glutathione peroxidase activity to 5.7% of that in selenium-supplemented (0.5 ppm selenium as Na2SeO3) rats. Aniline (60 mg/kg, i.p.) resulted in no significant difference in methemoglobin and blood reduced glutathione (GSH) levels between Se-deficient and Se-supplemented rats. A lowered aniline dose (36 mg/kg, i.p.) also resulted in no difference in methemoglobin levels. The selenium-deficient rat was able to reduce methemoglobin induced by aniline as efficiently as the selenium-sufficient rat.

Original languageEnglish
Pages (from-to)205-210
Number of pages6
JournalToxicology Letters
Volume25
Issue number2
DOIs
StatePublished - May 1985

Keywords

  • Selenium
  • analine
  • anemia
  • net hemoglobin
  • oxidation
  • toxicity

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