Dielectrophoresis and electrorotation of spheroidal cells after nsPEF induced electroporation

Qin Hu, Olaoluwa Fadiran, Wenjun Li, Ravindra P. Joshi

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

3 Scopus citations

Abstract

The impact of nanosecond, pulsed electric fields (nsPEF) induced biological membrane electroporation on the Clausius-Mossotti (C-M) factor is studied. The electrorotational speed, which is proportional to the imaginary part of the C-M factor, can be used for the noninvasive detection and monitoring of cellular membrane poration. Also, the dielectrophoresis (DEP) characteristics of normal and malignant white cells are different and one cell type can be more prone to be porated than another. These results point to the possibility of judiciously selecting electrical parameters for effective cell separation, especially in high conductivity media.

Original languageEnglish
Title of host publication2010 4th International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2010
DOIs
StatePublished - 2010
Event4th International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2010 - Chengdu, China
Duration: Jun 18 2010Jun 20 2010

Publication series

Name2010 4th International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2010

Conference

Conference4th International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2010
Country/TerritoryChina
CityChengdu
Period06/18/1006/20/10

Keywords

  • Bioelectric simulation
  • Cellular electroporation
  • Spheroidal cell
  • Transmembrane voltag
  • Ultrashort pulse

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