Diastereoselective synthesis of poly-substituted Sfaimidazolidine-2-thiones via microwave-assisted three-component [2+2+1] heterocyclizations

Jie Yu Hu, Yi Yun Gao, Wen Wen Zhang, Ke Ying Zhang, Wen Lian Li, Wen Juan Hao, Bo Jiang, Guigen Li

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

- An efficient and simple three-component reaction of arylglyoxals, isothiocyanates and arylamines has been developed, delivering poly-substituted 5y«-imidazolidine-2-thione derivatives with high diastereo- and regioselectivity (up to > 99:1). The microwave-assisted transformation is easy to perform simply by mixing readily available starting materials, thereby featuring mild reaction conditions, bond-forming efficiency and atom-economy.

Original languageEnglish
Pages (from-to)267-278
Number of pages12
JournalHeterocycles
Volume99
Issue number1
DOIs
StatePublished - 2019

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