Developmental toxicity of diacetoxyscirpenol in the mouse

K Mayura, Ernest Smith, B. A. Clement, R. B. Harvey, L. F. Kubena, T. D. Phillips

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Mycotoxins (frequently referred to as secondary metabolites of toxigenic fungi) are commonly found in foodstuffs and are important because of their association with disease. The mycotoxin diacetoxyscirpenol, or 3-hydroxy-4,15-diacetoxy-12,13-epoxytrichothec-9-ene (DAS), is produced by numerous species of Fusarium and is reportedly toxic to humans and animals. The teratogenic potential of DAS was determined in time-mated ICR mice. DAS (dissolved in a 1:9 mixture of propylene glycol/saline) was administered intraperitoneally to pregnant mice at levels of 1.0, 1.5, 2.0, 3.0 and 6.0 mg/kg body weight in a single dose on one of gestation days 7-11 during the period of organogenesis. Term fetuses were examined for anomalies by routine teratologic procedures. Reabsorption frequency was dose-related and occurred as follows: 100% at 6.0 mg/kg on all gestation days tested; 90-99% at 3.0 mg/kg on days 7-9 and 100% on days 10 and 11; 26-51% at 2.0 mg/kg on days 7-9 and 100% on days 10 and 11; 9-7
Original languageEnglish
Pages (from-to)245-55
StatePublished - Sep 1 1987

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    Mayura, K., Smith, E., Clement, B. A., Harvey, R. B., Kubena, L. F., & Phillips, T. D. (1987). Developmental toxicity of diacetoxyscirpenol in the mouse. Toxicology, 245-55.