Developmental programming of cardiovascular disorders: Focus on hypertension

Sheba M.J. Mohankumar, Andrew King, Andrew C. Shin, Madhu P. Sirivelu, P. S. Mohankumar, Gregory D. Fink

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations

Abstract

Increasing evidence suggests that adult cardiovascular disorders, e.g. hypertension, can be "programmed" in utero. The mechanisms that affect the developing fetus and lead to future cardiovascular disease are not fully established. This review addresses the possible involvement of maternal nutrition, sex steroids and other endocrine factors in the programming of hypertension in adulthood. Some possible mechanisms of subsequent development of hypertension in adulthood, such as elevated sympathetic and renin-angiotensin system activity, and failure of nephron development, also are discussed. Previous studies suggest that maternal undernutrition could be a major factor in fetal programming, but in light of the increased worldwide prevalence of obesity, maternal overnutrition is now receiving increased attention. Special emphasis is given here to this phenomenon. Obesity is associated with increased serum and tissue levels of proinflammatory cytokines, and loss of sensitivity to the adipokine leptin. It is postulated that this causes dysregulation of the hypothalamo-pituitary-adrenal axis, resulting in increased levels of circulating glucocorticoids. These factors could play a major role in programming, during the in utero period, of future hypertension in the offspring of obese mothers.

Original languageEnglish
Pages (from-to)115-125
Number of pages11
JournalReviews in Endocrine and Metabolic Disorders
Volume8
Issue number2
DOIs
StatePublished - Jun 2007

Keywords

  • Cardiovascular disorders
  • Developmental programming
  • Hypertension
  • Obesity

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