Determination of Drugs and Metabolites in Raw Wastewater Using Liquid Chromatography – Mass Spectrometry (LC-MS)

David Klein, Gaurav Pandee, Brett Blackwell, Kathy Sperry

Research output: Contribution to journalArticlepeer-review

Abstract

A previous study in Lubbock, TX detected the cocaine metabolite benzoylecgonine in wastewater entering the municipal wastewater treatment plant. This work was conducted using chemical derivatization followed by gas chromatography-mass spectrometry (GC-MS) determination. Here we report using liquid chromatography-mass spectrometry (LC-MS) for determination of drug metabolites isolated from wastewater by solid phase extraction (SPE). Using the LC-MS method, chemical derivatization is eliminated and multiple analytes can be determined in a single run. The results obtained showed that several compounds from different drug classes were detected. Compounds observed included cocaine, heroin, tetrahydrocannabinol, amphetamine, and some benzodiazepine compounds.
Original languageEnglish
Pages (from-to)2-5
JournalForensic Research
StatePublished - Jan 25 2015

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