Design and 3D printing of hierarchical tissue engineering scaffolds based on mechanics and biology perspectives

Paul Egan, Stephen J. Ferguson, Kristina Shea

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

5 Scopus citations

Abstract

Continued scientific research is crucial for developing new biomedical products, such as tissue engineering scaffolds, that are difficult to optimize due to the complexity of interfacing mechanical and biological systems. In this paper, mechanical and biological perspectives are used to propose and implement an approach for designing hierarchical scaffolds that provide structural support in the body as tissue regenerates. Three sequential steps are proposed for defining design needs, generating design alternatives, and fabricating design prototypes. Design needs are determined by considering mechanical and biological performance requirements, experimental procedures, and fabrication constraints. The primary mechanical requirement is a scaffold's need to maintain structural integrity, while biologically the scaffold should promote cellular growth. Scaffold design alternatives of four topology types are generated by altering design parameters that describe a scaffold's structure. Trade-offs are revealed for scaffold porosity and surface area properties that are known to influence mechanical and biological scaffold performance. Scaffolds of each topology type are designed with 80% porosity and fabricated, which enables their potential use in scientific experiments to measure how property trade-offs influence scaffold performance. On the basis of currently available knowledge, a to-scale spinal scaffold implant is designed and fabricated with a graphically maximized surface area to porosity ratio for a hierarchical scaffold, which represents a potentially high performing design from both mechanical and biological perspectives. These results demonstrate the importance of multidisciplinary approaches for designing complex biomedical tissue scaffolds that could significantly improve healthcare through the development of new clinical products.

Original languageEnglish
Title of host publication28th International Conference on Design Theory and Methodology
PublisherAmerican Society of Mechanical Engineers (ASME)
ISBN (Electronic)9780791850190
DOIs
StatePublished - 2016
EventASME 2016 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, IDETC/CIE 2016 - Charlotte, United States
Duration: Aug 21 2016Aug 24 2016

Publication series

NameProceedings of the ASME Design Engineering Technical Conference
Volume7

Conference

ConferenceASME 2016 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, IDETC/CIE 2016
Country/TerritoryUnited States
CityCharlotte
Period08/21/1608/24/16

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