TY - GEN
T1 - Design and 3D printing of hierarchical tissue engineering scaffolds based on mechanics and biology perspectives
AU - Egan, Paul
AU - Ferguson, Stephen J.
AU - Shea, Kristina
N1 - Publisher Copyright:
Copyright © 2016 by ASME.
PY - 2016
Y1 - 2016
N2 - Continued scientific research is crucial for developing new biomedical products, such as tissue engineering scaffolds, that are difficult to optimize due to the complexity of interfacing mechanical and biological systems. In this paper, mechanical and biological perspectives are used to propose and implement an approach for designing hierarchical scaffolds that provide structural support in the body as tissue regenerates. Three sequential steps are proposed for defining design needs, generating design alternatives, and fabricating design prototypes. Design needs are determined by considering mechanical and biological performance requirements, experimental procedures, and fabrication constraints. The primary mechanical requirement is a scaffold's need to maintain structural integrity, while biologically the scaffold should promote cellular growth. Scaffold design alternatives of four topology types are generated by altering design parameters that describe a scaffold's structure. Trade-offs are revealed for scaffold porosity and surface area properties that are known to influence mechanical and biological scaffold performance. Scaffolds of each topology type are designed with 80% porosity and fabricated, which enables their potential use in scientific experiments to measure how property trade-offs influence scaffold performance. On the basis of currently available knowledge, a to-scale spinal scaffold implant is designed and fabricated with a graphically maximized surface area to porosity ratio for a hierarchical scaffold, which represents a potentially high performing design from both mechanical and biological perspectives. These results demonstrate the importance of multidisciplinary approaches for designing complex biomedical tissue scaffolds that could significantly improve healthcare through the development of new clinical products.
AB - Continued scientific research is crucial for developing new biomedical products, such as tissue engineering scaffolds, that are difficult to optimize due to the complexity of interfacing mechanical and biological systems. In this paper, mechanical and biological perspectives are used to propose and implement an approach for designing hierarchical scaffolds that provide structural support in the body as tissue regenerates. Three sequential steps are proposed for defining design needs, generating design alternatives, and fabricating design prototypes. Design needs are determined by considering mechanical and biological performance requirements, experimental procedures, and fabrication constraints. The primary mechanical requirement is a scaffold's need to maintain structural integrity, while biologically the scaffold should promote cellular growth. Scaffold design alternatives of four topology types are generated by altering design parameters that describe a scaffold's structure. Trade-offs are revealed for scaffold porosity and surface area properties that are known to influence mechanical and biological scaffold performance. Scaffolds of each topology type are designed with 80% porosity and fabricated, which enables their potential use in scientific experiments to measure how property trade-offs influence scaffold performance. On the basis of currently available knowledge, a to-scale spinal scaffold implant is designed and fabricated with a graphically maximized surface area to porosity ratio for a hierarchical scaffold, which represents a potentially high performing design from both mechanical and biological perspectives. These results demonstrate the importance of multidisciplinary approaches for designing complex biomedical tissue scaffolds that could significantly improve healthcare through the development of new clinical products.
UR - http://www.scopus.com/inward/record.url?scp=85007281118&partnerID=8YFLogxK
U2 - 10.1115/DETC201659554
DO - 10.1115/DETC201659554
M3 - Conference contribution
AN - SCOPUS:85007281118
T3 - Proceedings of the ASME Design Engineering Technical Conference
BT - 28th International Conference on Design Theory and Methodology
PB - American Society of Mechanical Engineers (ASME)
T2 - ASME 2016 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, IDETC/CIE 2016
Y2 - 21 August 2016 through 24 August 2016
ER -