TY - JOUR
T1 - Depression, stressful life events, and the impact of variation in the serotonin transporter
T2 - Findings from the national longitudinal study of adolescent to adult health (Add Health)
AU - Haberstick, Brett C.
AU - Boardman, Jason D.
AU - Wagner, Brandon
AU - Smolen, Andrew
AU - Hewitt, John K.
AU - Killeya-Jones, Ley A.
AU - Tabor, Joyce
AU - Halpern, Carolyn T.
AU - Brummett, Beverly H.
AU - Williams, Redford B.
AU - Siegler, Ilene C.
AU - Hopfer, Christian J.
AU - Harris, Kathleen Mullan
N1 - Funding Information:
This research uses data from Add Health, a program project directed by Kathleen Mullan Harris and designed by J. Richard Udry, Peter S. Bearman, and Kathleen Mullan Harris at the University of North Carolina at Chapel Hill, and funded by grant P01-HD31921 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development, with cooperative funding from 23 other federal agencies and foundations. Special acknowledgement is due Ronald R. Rindfuss and Barbara Entwisle for assistance in the original design. Information on how to obtain Add Health data files is available at the Add Health website ( http://www.cpc.unc.edu/addhealth ). This research was also supported by grant P01-HL36587 from the National Heart, Lung, Blood Institute to Redford Williams and by grant AG046938 from the National Institute on Aging to Chandra A. Reynolds and Sally Wadsworth (Co-PI’s)
Funding Information:
This work was supported by National Institute for Child Health and Human Development, P01-HD31921; National Heart, Lung, Blood Institute, P01-HL36587 (to Redford Williams); National Institute on Aging, AG046938 (to Chandra A. Reynolds and Sally Wadsworth).
Publisher Copyright:
© 2016 Haberstick et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2016/3
Y1 - 2016/3
N2 - Background The low transcriptionally efficient short-Allele of the 5HTTLPR serotonin transporter polymorphism has been implicated to moderate the relationship between the experience of stressful life events (SLEs) and depression. Despite numerous attempts at replicating this observation, results remain inconclusive. Methods We examined this relationship in young-Adult Non-Hispanic white males and females between the ages of 22 and 26 (n = 4724) participating in the National Longitudinal Study of Adolescent to Adult Health (Add Health) with follow-up information every six years since 1995. Results Linear and logistic regression models, corrected for multiple testing, indicated that carriers of one or more of the S-Alleles were more sensitive to stress than those with two L-Alleles and at a higher risk for depression. This relationship behaved in a dose-response manner such that the risk for depression was greatest among those who reported experiencing higher numbers of SLEs. In post-hoc analyses we were not able to replicate an interactioneffect for suicide ideation but did find suggestive evidence that the effects of SLEs and 5HTTLPR on suicide ideation differed for males and females. There were no effects of childhood maltreatment.
AB - Background The low transcriptionally efficient short-Allele of the 5HTTLPR serotonin transporter polymorphism has been implicated to moderate the relationship between the experience of stressful life events (SLEs) and depression. Despite numerous attempts at replicating this observation, results remain inconclusive. Methods We examined this relationship in young-Adult Non-Hispanic white males and females between the ages of 22 and 26 (n = 4724) participating in the National Longitudinal Study of Adolescent to Adult Health (Add Health) with follow-up information every six years since 1995. Results Linear and logistic regression models, corrected for multiple testing, indicated that carriers of one or more of the S-Alleles were more sensitive to stress than those with two L-Alleles and at a higher risk for depression. This relationship behaved in a dose-response manner such that the risk for depression was greatest among those who reported experiencing higher numbers of SLEs. In post-hoc analyses we were not able to replicate an interactioneffect for suicide ideation but did find suggestive evidence that the effects of SLEs and 5HTTLPR on suicide ideation differed for males and females. There were no effects of childhood maltreatment.
UR - http://www.scopus.com/inward/record.url?scp=84961185399&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0148373
DO - 10.1371/journal.pone.0148373
M3 - Article
C2 - 26938215
AN - SCOPUS:84961185399
VL - 11
JO - PLoS ONE
JF - PLoS ONE
SN - 1932-6203
IS - 3
M1 - e0148373
ER -