DDQ-Mediated Three-Component Dioxygenation of Alkenes

Tian Shu Zhang, Yan Jie Xiong, Wen Juan Hao, Xiao Tong Zhu, Shu Liang Wang, Guigen Li, Shu Jiang Tu, Bo Jiang

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


A new DDQ-mediated three-component dioxygenation of alkenes has been established, providing a direct and metal-free access toward densely functionalized 4,5-dichloro-3-hydroxyphthalonitrile derivatives with generally good to excellent yields under mild conditions. During this process, DDQ plays dual roles as both a dehydrogenation reagent and a coupling partner, enabling oxidative coupling to form two C-O functionalities in a highly atom-economy fashion.

Original languageEnglish
Pages (from-to)9350-9355
Number of pages6
JournalJournal of Organic Chemistry
Issue number19
StatePublished - Oct 7 2016


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