Cytotoxicity of abietane diterpenoids from Salvia multicaulis towards multidrug-resistant cancer cells

Mohamed Elamir F. Hegazy, Ahmed R. Hamed, Ali M. El-Halawany, Taha A. Hussien, Sara Abdelfatah, Shinji Ohta, Paul W. Paré, Essam Abdel-Sattar, Thomas Efferth

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Diterpenoids salvimulticanol (1) and salvimulticaoic acid (2) together with known diterpenoid (3–6) were isolated from Salvia multicaulis. Structures were elucidated by spectroscopic techniques including HRESIMS as well as 1D-, and 2D-NMR. In-vitro cytotoxicity was assayed against human cancer cell lines. As several metabolites exhibited activity against drug-resistance lines, compounds were screened against a panel of human drug-sensitive and multidrug-resistant cancer lines. A proposed biosynthetic pathway for these new diterpenoids (1–2) as well as the cytotoxic structure-activity relationship of all identified compounds were discussed. Compound 1 and 6 showed the most potent cytotoxicity with IC50 11.58 and 4.13 towards leukemia cell lines CCRF-CEM and CEM-ADR5000, respectively.

Original languageEnglish
Pages (from-to)54-60
Number of pages7
JournalFitoterapia
Volume130
DOIs
StatePublished - Oct 2018

Keywords

  • Abietane diterpenoids
  • Cytotoxic activity
  • Lamiaceae
  • Multidrug resistance
  • Salvia multicaulis

Fingerprint

Dive into the research topics of 'Cytotoxicity of abietane diterpenoids from Salvia multicaulis towards multidrug-resistant cancer cells'. Together they form a unique fingerprint.

Cite this