Cytotoxicity of abietane diterpenoids from Salvia multicaulis towards multidrug-resistant cancer cells

Mohamed Elamir F. Hegazy, Ahmed R. Hamed, Ali M. El-Halawany, Taha A. Hussien, Sara Abdelfatah, Shinji Ohta, Paul W. Paré, Essam Abdel-Sattar, Thomas Efferth

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Abstract

Diterpenoids salvimulticanol (1) and salvimulticaoic acid (2) together with known diterpenoid (3–6) were isolated from Salvia multicaulis. Structures were elucidated by spectroscopic techniques including HRESIMS as well as 1D-, and 2D-NMR. In-vitro cytotoxicity was assayed against human cancer cell lines. As several metabolites exhibited activity against drug-resistance lines, compounds were screened against a panel of human drug-sensitive and multidrug-resistant cancer lines. A proposed biosynthetic pathway for these new diterpenoids (1–2) as well as the cytotoxic structure-activity relationship of all identified compounds were discussed. Compound 1 and 6 showed the most potent cytotoxicity with IC50 11.58 and 4.13 towards leukemia cell lines CCRF-CEM and CEM-ADR5000, respectively.

Original languageEnglish
Pages (from-to)54-60
Number of pages7
JournalFitoterapia
Volume130
DOIs
StatePublished - Oct 2018

Keywords

  • Abietane diterpenoids
  • Cytotoxic activity
  • Lamiaceae
  • Multidrug resistance
  • Salvia multicaulis

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    Hegazy, M. E. F., Hamed, A. R., El-Halawany, A. M., Hussien, T. A., Abdelfatah, S., Ohta, S., Paré, P. W., Abdel-Sattar, E., & Efferth, T. (2018). Cytotoxicity of abietane diterpenoids from Salvia multicaulis towards multidrug-resistant cancer cells. Fitoterapia, 130, 54-60. https://doi.org/10.1016/j.fitote.2018.08.002