Abstract
Diterpenoids salvimulticanol (1) and salvimulticaoic acid (2) together with known diterpenoid (3–6) were isolated from Salvia multicaulis. Structures were elucidated by spectroscopic techniques including HRESIMS as well as 1D-, and 2D-NMR. In-vitro cytotoxicity was assayed against human cancer cell lines. As several metabolites exhibited activity against drug-resistance lines, compounds were screened against a panel of human drug-sensitive and multidrug-resistant cancer lines. A proposed biosynthetic pathway for these new diterpenoids (1–2) as well as the cytotoxic structure-activity relationship of all identified compounds were discussed. Compound 1 and 6 showed the most potent cytotoxicity with IC50 11.58 and 4.13 towards leukemia cell lines CCRF-CEM and CEM-ADR5000, respectively.
Original language | English |
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Pages (from-to) | 54-60 |
Number of pages | 7 |
Journal | Fitoterapia |
Volume | 130 |
DOIs | |
State | Published - Oct 2018 |
Keywords
- Abietane diterpenoids
- Cytotoxic activity
- Lamiaceae
- Multidrug resistance
- Salvia multicaulis