Abstract
Three saponin glycosides have been isolated and characterized from Teucrium polium L. (Lamiaceae). The
compounds were isolated from a MeOH aerial plant extract. The structures were elucidated based on
spectroscopic methods including UV, IR, 1D and 2D NMR, and HRESIMS data analyses. The identified
compounds were evaluated for anticancer effects against 60 human tumor cell lines (NCI). The
triterpene glycoside, poliusaposide C completely inhibited the growth of a breast and colon cancer cell
line and partially inhibited the growth of a colon, renal and melanoma cell line. Structure–anticancer
activity relationships are discussed.
Original language | English |
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Pages (from-to) | 27126-27133 |
Journal | Default journal |
State | Published - Mar 2015 |