Cytotoxic saponin poliusaposide from Teucrium polium

Yehia Mechref; Wael Elmasri; Mohamed-Elamir F. Hegazy; Paul Pare

Cytotoxic saponin poliusaposide from Teucrium polium

Yehia Mechref, Wael Elmasri, Mohamed-Elamir F. Hegazy, Paul Pare

Research output: Contribution to journal › Article

Abstract

Three saponin glycosides have been isolated and characterized from Teucrium polium L. (Lamiaceae). The compounds were isolated from a MeOH aerial plant extract. The structures were elucidated based on spectroscopic methods including UV, IR, 1D and 2D NMR, and HRESIMS data analyses. The identified compounds were evaluated for anticancer effects against 60 human tumor cell lines (NCI). The triterpene glycoside, poliusaposide C completely inhibited the growth of a breast and colon cancer cell line and partially inhibited the growth of a colon, renal and melanoma cell line. Structure–anticancer activity relationships are discussed.

Original language	English
Pages (from-to)	27126-27133
Journal	Default journal
State	Published - Mar 2015

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title = "Cytotoxic saponin poliusaposide from Teucrium polium",

abstract = "Three saponin glycosides have been isolated and characterized from Teucrium polium L. (Lamiaceae). The compounds were isolated from a MeOH aerial plant extract. The structures were elucidated based on spectroscopic methods including UV, IR, 1D and 2D NMR, and HRESIMS data analyses. The identified compounds were evaluated for anticancer effects against 60 human tumor cell lines (NCI). The triterpene glycoside, poliusaposide C completely inhibited the growth of a breast and colon cancer cell line and partially inhibited the growth of a colon, renal and melanoma cell line. Structure–anticancer activity relationships are discussed.",

author = "Yehia Mechref and Wael Elmasri and Hegazy, {Mohamed-Elamir F.} and Paul Pare",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2015.",

year = "2015",

month = mar,

language = "English",

pages = "27126--27133",

journal = "Default journal",

publisher = "Current Opinion in Endocrinology Diabetes and Obesity",

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T1 - Cytotoxic saponin poliusaposide from Teucrium polium

AU - Mechref, Yehia

AU - Elmasri, Wael

AU - Hegazy, Mohamed-Elamir F.

AU - Pare, Paul

PY - 2015/3

Y1 - 2015/3

N2 - Three saponin glycosides have been isolated and characterized from Teucrium polium L. (Lamiaceae). The compounds were isolated from a MeOH aerial plant extract. The structures were elucidated based on spectroscopic methods including UV, IR, 1D and 2D NMR, and HRESIMS data analyses. The identified compounds were evaluated for anticancer effects against 60 human tumor cell lines (NCI). The triterpene glycoside, poliusaposide C completely inhibited the growth of a breast and colon cancer cell line and partially inhibited the growth of a colon, renal and melanoma cell line. Structure–anticancer activity relationships are discussed.

AB - Three saponin glycosides have been isolated and characterized from Teucrium polium L. (Lamiaceae). The compounds were isolated from a MeOH aerial plant extract. The structures were elucidated based on spectroscopic methods including UV, IR, 1D and 2D NMR, and HRESIMS data analyses. The identified compounds were evaluated for anticancer effects against 60 human tumor cell lines (NCI). The triterpene glycoside, poliusaposide C completely inhibited the growth of a breast and colon cancer cell line and partially inhibited the growth of a colon, renal and melanoma cell line. Structure–anticancer activity relationships are discussed.

M3 - Article

SP - 27126

EP - 27133

JO - Default journal

JF - Default journal

ER -

Cytotoxic saponin poliusaposide from Teucrium polium

Abstract

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