Cytotoxic saponin poliusaposide from Teucrium polium

Wael A. Elmasri, Mohamed Elamir F. Hegazy, Yehia Mechref, Paul W. Paré

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Three saponin glycosides have been isolated and characterized from Teucrium polium L. (Lamiaceae). The compounds were isolated from a MeOH aerial plant extract. The structures were elucidated based on spectroscopic methods including UV, IR, 1D and 2D NMR, and HRESIMS data analyses. The identified compounds were evaluated for anticancer effects against 60 human tumor cell lines (NCI). The triterpene glycoside, poliusaposide C completely inhibited the growth of a breast and colon cancer cell line and partially inhibited the growth of a colon, renal and melanoma cell line. Structure-anticancer activity relationships are discussed.

Original languageEnglish
Pages (from-to)27126-27133
Number of pages8
JournalRSC Advances
Volume5
Issue number34
DOIs
StatePublished - 2015

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