Cytotoxic cembranoids from the Red Sea soft coral Sarcophyton glaucum

Mohamed Elamir F. Hegazy, Ahmed A. El-Beih, Alaa Y. Moustafa, Abdelhamed A. Hamdy, Montaser A. Alhammady, Rehab M. Selim, Mohamed Abdel-Rehim, Paul W. Paré

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Abstract

One new cembrane diterpene, 2R,7R,8R-dihydroxydeepoxysarcophine (1), together with three known compounds, 7α,8β-dihydroxy- deepoxysarcophine (2), 7β-acetoxy-8α-hydroxydeepoxysarcophine (3), and sarcophine (4), have been isolated from the Red Sea soft coral Sarcophyton glaucum. Their structures were determined using 1D and 2D NMR spectroscopy. 7β-Acetoxy-8α-hydroxydeepoxysarcophine (3) exhibits cytotoxic activity against HepG2, HCT-116, and HeLa cells with IC 50 values of 3.6, 2.3, and 6.7 μg/mL, respectively.

Original languageEnglish
Pages (from-to)1809-1812
Number of pages4
JournalNatural Product Communications
Volume6
Issue number12
StatePublished - Dec 20 2011

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Keywords

  • Cembrane diterpenes
  • Dihydroxydeepoxysarcophine
  • Sarcophine
  • Sarcophyton glaucum

Cite this

Hegazy, M. E. F., El-Beih, A. A., Moustafa, A. Y., Hamdy, A. A., Alhammady, M. A., Selim, R. M., Abdel-Rehim, M., & Paré, P. W. (2011). Cytotoxic cembranoids from the Red Sea soft coral Sarcophyton glaucum. Natural Product Communications, 6(12), 1809-1812.