Cytotoxic Cembranoids from the Red Sea Soft Coral

Paul Pare; Mohamed-Elamir F. Hegazya; Ahmed A. El-Beih; Alaa Y. Moustafa; Abdelhamed A. Hamdy; Montaser A. Alhammady; Rehab M. Selim; Mohamed Abdel-Rehim

Cytotoxic Cembranoids from the Red Sea Soft Coral

Paul Pare, Mohamed-Elamir F. Hegazya, Ahmed A. El-Beih, Alaa Y. Moustafa, Abdelhamed A. Hamdy, Montaser A. Alhammady, Rehab M. Selim, Mohamed Abdel-Rehim

Research output: Contribution to journal › Article › peer-review

Abstract

One new cembrane diterpene, 2R,7R,8R-dihydroxydeepoxysarcophine (1), together with three known compounds, 7α,8β-dihydroxydeepoxysarcophine (2), 7β-acetoxy-8α-hydroxydeepoxysarcophine (3), and sarcophine (4), have been isolated from the Red Sea soft coral Sarcophyton glaucum. Their structures were determined using 1D and 2D NMR spectroscopy. 7β-Acetoxy-8α-hydroxydeepoxysarcophine (3) exhibits cytotoxic activity against HepG2, HCT-116, and HeLa cells with IC50 values of 3.6, 2.3, and 6.7 μg/mL, respectively.

Original language	English
Pages (from-to)	1809-1812
Journal	Natural Product Communications
State	Published - Aug 31 2011

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title = "Cytotoxic Cembranoids from the Red Sea Soft Coral",

abstract = "One new cembrane diterpene, 2R,7R,8R-dihydroxydeepoxysarcophine (1), together with three known compounds, 7α,8β-dihydroxydeepoxysarcophine (2), 7β-acetoxy-8α-hydroxydeepoxysarcophine (3), and sarcophine (4), have been isolated from the Red Sea soft coral Sarcophyton glaucum. Their structures were determined using 1D and 2D NMR spectroscopy. 7β-Acetoxy-8α-hydroxydeepoxysarcophine (3) exhibits cytotoxic activity against HepG2, HCT-116, and HeLa cells with IC50 values of 3.6, 2.3, and 6.7 μg/mL, respectively.",

author = "Paul Pare and Hegazya, {Mohamed-Elamir F.} and El-Beih, {Ahmed A.} and Moustafa, {Alaa Y.} and Hamdy, {Abdelhamed A.} and Alhammady, {Montaser A.} and Selim, {Rehab M.} and Mohamed Abdel-Rehim",

year = "2011",

month = aug,

day = "31",

language = "English",

pages = "1809--1812",

journal = "Natural Product Communications",

}

TY - JOUR

T1 - Cytotoxic Cembranoids from the Red Sea Soft Coral

AU - Pare, Paul

AU - Hegazya, Mohamed-Elamir F.

AU - El-Beih, Ahmed A.

AU - Moustafa, Alaa Y.

AU - Hamdy, Abdelhamed A.

AU - Alhammady, Montaser A.

AU - Selim, Rehab M.

AU - Abdel-Rehim, Mohamed

PY - 2011/8/31

Y1 - 2011/8/31

N2 - One new cembrane diterpene, 2R,7R,8R-dihydroxydeepoxysarcophine (1), together with three known compounds, 7α,8β-dihydroxydeepoxysarcophine (2), 7β-acetoxy-8α-hydroxydeepoxysarcophine (3), and sarcophine (4), have been isolated from the Red Sea soft coral Sarcophyton glaucum. Their structures were determined using 1D and 2D NMR spectroscopy. 7β-Acetoxy-8α-hydroxydeepoxysarcophine (3) exhibits cytotoxic activity against HepG2, HCT-116, and HeLa cells with IC50 values of 3.6, 2.3, and 6.7 μg/mL, respectively.

AB - One new cembrane diterpene, 2R,7R,8R-dihydroxydeepoxysarcophine (1), together with three known compounds, 7α,8β-dihydroxydeepoxysarcophine (2), 7β-acetoxy-8α-hydroxydeepoxysarcophine (3), and sarcophine (4), have been isolated from the Red Sea soft coral Sarcophyton glaucum. Their structures were determined using 1D and 2D NMR spectroscopy. 7β-Acetoxy-8α-hydroxydeepoxysarcophine (3) exhibits cytotoxic activity against HepG2, HCT-116, and HeLa cells with IC50 values of 3.6, 2.3, and 6.7 μg/mL, respectively.

M3 - Article

SP - 1809

EP - 1812

JO - Natural Product Communications

JF - Natural Product Communications

ER -