TY - JOUR
T1 - Cytotoxic Cembranoids from the Red Sea Soft Coral
AU - Pare, Paul
AU - Hegazya, Mohamed-Elamir F.
AU - El-Beih, Ahmed A.
AU - Moustafa, Alaa Y.
AU - Hamdy, Abdelhamed A.
AU - Alhammady, Montaser A.
AU - Selim, Rehab M.
AU - Abdel-Rehim, Mohamed
PY - 2011/8/31
Y1 - 2011/8/31
N2 - One new cembrane diterpene, 2R,7R,8R-dihydroxydeepoxysarcophine (1), together with three known compounds, 7α,8β-dihydroxydeepoxysarcophine (2), 7β-acetoxy-8α-hydroxydeepoxysarcophine (3), and sarcophine (4), have been isolated from the Red Sea soft coral Sarcophyton glaucum. Their structures were determined using 1D and 2D NMR spectroscopy. 7β-Acetoxy-8α-hydroxydeepoxysarcophine (3) exhibits cytotoxic activity against HepG2, HCT-116, and HeLa cells with IC50 values of 3.6, 2.3, and 6.7 μg/mL, respectively.
AB - One new cembrane diterpene, 2R,7R,8R-dihydroxydeepoxysarcophine (1), together with three known compounds, 7α,8β-dihydroxydeepoxysarcophine (2), 7β-acetoxy-8α-hydroxydeepoxysarcophine (3), and sarcophine (4), have been isolated from the Red Sea soft coral Sarcophyton glaucum. Their structures were determined using 1D and 2D NMR spectroscopy. 7β-Acetoxy-8α-hydroxydeepoxysarcophine (3) exhibits cytotoxic activity against HepG2, HCT-116, and HeLa cells with IC50 values of 3.6, 2.3, and 6.7 μg/mL, respectively.
M3 - Article
SP - 1809
EP - 1812
JO - Natural Product Communications
JF - Natural Product Communications
ER -