Cyclooxygenase (COX)-1 and -2 inhibitory labdane diterpenes from Crassocephalum mannii

Mohamed Elamir F. Hegazy; Shinji Ohta; Fathy F. Abdel-Latif; Hazem A. Albadry; Emi Ohta; Paul W. Paré; Toshifumi Hirata

doi:10.1021/np800017x

Cyclooxygenase (COX)-1 and -2 inhibitory labdane diterpenes from Crassocephalum mannii

Mohamed Elamir F. Hegazy, Shinji Ohta, Fathy F. Abdel-Latif, Hazem A. Albadry, Emi Ohta, Paul W. Paré, Toshifumi Hirata

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Two new labdane diterpenes, 8α,19-dihydroxylabd-13E-en-15-oic acid (1) and 13,14,15,16-tetranorlabdane-8α,12,14-triol (2), as well as an acetylated derivative, 8α-O-β-D-glucopyranosyllabd-13E-ene-15,19- diol-8α-2′,3′,4′,6′-hexaacetate (3a), were isolated from the aerial parts of Crassocephalum mannii. The structures of 1, 2, and 3a were elucidated by spectroscopic data analysis. Selective inhibitory activity for 1 and 2 and their acetate derivatives, 1a and 2a, against cyclooxygenases (COX-1 and COX-2) was detected.

Original language	English
Pages (from-to)	1070-1073
Number of pages	4
Journal	Journal of Natural Products
Volume	71
Issue number	6
DOIs	https://doi.org/10.1021/np800017x
State	Published - Jun 2008

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@article{f82202535959477ba8d575a934522cbc,

title = "Cyclooxygenase (COX)-1 and -2 inhibitory labdane diterpenes from Crassocephalum mannii",

abstract = "Two new labdane diterpenes, 8α,19-dihydroxylabd-13E-en-15-oic acid (1) and 13,14,15,16-tetranorlabdane-8α,12,14-triol (2), as well as an acetylated derivative, 8α-O-β-D-glucopyranosyllabd-13E-ene-15,19- diol-8α-2′,3′,4′,6′-hexaacetate (3a), were isolated from the aerial parts of Crassocephalum mannii. The structures of 1, 2, and 3a were elucidated by spectroscopic data analysis. Selective inhibitory activity for 1 and 2 and their acetate derivatives, 1a and 2a, against cyclooxygenases (COX-1 and COX-2) was detected.",

author = "Hegazy, {Mohamed Elamir F.} and Shinji Ohta and Abdel-Latif, {Fathy F.} and Albadry, {Hazem A.} and Emi Ohta and Par{\'e}, {Paul W.} and Toshifumi Hirata",

year = "2008",

month = jun,

doi = "10.1021/np800017x",

language = "English",

volume = "71",

pages = "1070--1073",

journal = "Journal of Natural Products",

issn = "0163-3864",

number = "6",

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TY - JOUR

T1 - Cyclooxygenase (COX)-1 and -2 inhibitory labdane diterpenes from Crassocephalum mannii

AU - Hegazy, Mohamed Elamir F.

AU - Ohta, Shinji

AU - Abdel-Latif, Fathy F.

AU - Albadry, Hazem A.

AU - Ohta, Emi

AU - Paré, Paul W.

AU - Hirata, Toshifumi

PY - 2008/6

Y1 - 2008/6

N2 - Two new labdane diterpenes, 8α,19-dihydroxylabd-13E-en-15-oic acid (1) and 13,14,15,16-tetranorlabdane-8α,12,14-triol (2), as well as an acetylated derivative, 8α-O-β-D-glucopyranosyllabd-13E-ene-15,19- diol-8α-2′,3′,4′,6′-hexaacetate (3a), were isolated from the aerial parts of Crassocephalum mannii. The structures of 1, 2, and 3a were elucidated by spectroscopic data analysis. Selective inhibitory activity for 1 and 2 and their acetate derivatives, 1a and 2a, against cyclooxygenases (COX-1 and COX-2) was detected.

AB - Two new labdane diterpenes, 8α,19-dihydroxylabd-13E-en-15-oic acid (1) and 13,14,15,16-tetranorlabdane-8α,12,14-triol (2), as well as an acetylated derivative, 8α-O-β-D-glucopyranosyllabd-13E-ene-15,19- diol-8α-2′,3′,4′,6′-hexaacetate (3a), were isolated from the aerial parts of Crassocephalum mannii. The structures of 1, 2, and 3a were elucidated by spectroscopic data analysis. Selective inhibitory activity for 1 and 2 and their acetate derivatives, 1a and 2a, against cyclooxygenases (COX-1 and COX-2) was detected.

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