Cyclooxygenase (COX)-1 and -2 inhibitory labdane diterpenes from Crassocephalum mannii

Mohamed Elamir F. Hegazy, Shinji Ohta, Fathy F. Abdel-Latif, Hazem A. Albadry, Emi Ohta, Paul W. Paré, Toshifumi Hirata

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13 Scopus citations


Two new labdane diterpenes, 8α,19-dihydroxylabd-13E-en-15-oic acid (1) and 13,14,15,16-tetranorlabdane-8α,12,14-triol (2), as well as an acetylated derivative, 8α-O-β-D-glucopyranosyllabd-13E-ene-15,19- diol-8α-2′,3′,4′,6′-hexaacetate (3a), were isolated from the aerial parts of Crassocephalum mannii. The structures of 1, 2, and 3a were elucidated by spectroscopic data analysis. Selective inhibitory activity for 1 and 2 and their acetate derivatives, 1a and 2a, against cyclooxygenases (COX-1 and COX-2) was detected.

Original languageEnglish
Pages (from-to)1070-1073
Number of pages4
JournalJournal of Natural Products
Issue number6
StatePublished - Jun 2008


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