TY - JOUR
T1 - Cyclooxygenase (COX)-1 and -2 inhibitory labdane diterpenes from Crassocephalum mannii
AU - Hegazy, Mohamed Elamir F.
AU - Ohta, Shinji
AU - Abdel-Latif, Fathy F.
AU - Albadry, Hazem A.
AU - Ohta, Emi
AU - Paré, Paul W.
AU - Hirata, Toshifumi
PY - 2008/6
Y1 - 2008/6
N2 - Two new labdane diterpenes, 8α,19-dihydroxylabd-13E-en-15-oic acid (1) and 13,14,15,16-tetranorlabdane-8α,12,14-triol (2), as well as an acetylated derivative, 8α-O-β-D-glucopyranosyllabd-13E-ene-15,19- diol-8α-2′,3′,4′,6′-hexaacetate (3a), were isolated from the aerial parts of Crassocephalum mannii. The structures of 1, 2, and 3a were elucidated by spectroscopic data analysis. Selective inhibitory activity for 1 and 2 and their acetate derivatives, 1a and 2a, against cyclooxygenases (COX-1 and COX-2) was detected.
AB - Two new labdane diterpenes, 8α,19-dihydroxylabd-13E-en-15-oic acid (1) and 13,14,15,16-tetranorlabdane-8α,12,14-triol (2), as well as an acetylated derivative, 8α-O-β-D-glucopyranosyllabd-13E-ene-15,19- diol-8α-2′,3′,4′,6′-hexaacetate (3a), were isolated from the aerial parts of Crassocephalum mannii. The structures of 1, 2, and 3a were elucidated by spectroscopic data analysis. Selective inhibitory activity for 1 and 2 and their acetate derivatives, 1a and 2a, against cyclooxygenases (COX-1 and COX-2) was detected.
UR - http://www.scopus.com/inward/record.url?scp=47549104530&partnerID=8YFLogxK
U2 - 10.1021/np800017x
DO - 10.1021/np800017x
M3 - Article
C2 - 18473477
AN - SCOPUS:47549104530
VL - 71
SP - 1070
EP - 1073
JO - Journal of Natural Products
JF - Journal of Natural Products
SN - 0163-3864
IS - 6
ER -