Cross-Sectional Analysis of Longitudinal Mediation Processes

Kristine D. O'Laughlin, Monica J. Martin, Emilio Ferrer

Research output: Contribution to journalArticlepeer-review

118 Scopus citations


Statistical mediation analysis can help to identify and explain the mechanisms behind psychological processes. Examining a set of variables for mediation effects is a ubiquitous process in the social sciences literature; however, despite evidence suggesting that cross-sectional data can misrepresent the mediation of longitudinal processes, cross-sectional analyses continue to be used in this manner. Alternative longitudinal mediation models, including those rooted in a structural equation modeling framework (cross-lagged panel, latent growth curve, and latent difference score models) are currently available and may provide a better representation of mediation processes for longitudinal data. The purpose of this paper is twofold: first, we provide a comparison of cross-sectional and longitudinal mediation models; second, we advocate using models to evaluate mediation effects that capture the temporal sequence of the process under study. Two separate empirical examples are presented to illustrate differences in the conclusions drawn from cross-sectional and longitudinal mediation analyses. Findings from these examples yielded substantial differences in interpretations between the cross-sectional and longitudinal mediation models considered here. Based on these observations, researchers should use caution when attempting to use cross-sectional data in place of longitudinal data for mediation analyses.

Original languageEnglish
Pages (from-to)375-402
Number of pages28
JournalMultivariate Behavioral Research
Issue number3
StatePublished - May 4 2018


  • cross-sectional mediation
  • intervening variable
  • latent difference score models
  • latent growth models
  • longitudinal mediation


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