Coupling capillary electrochromatography with electrospray Fourier transform mass spectrometry for characterizing complex oligosaccharide pools

Amy H. Que, Yehia Mechref, Yunping Huang, John A. Taraszka, David E. Clemmer, Milos V. Novotny

Research output: Contribution to journalArticlepeer-review

68 Scopus citations

Abstract

To deal with the complexity of the glycan mixtures released from glycoproteins, an efficient form of microcolumn separations, capillary electrochromatography, has been combined with high-performance mass spectrometry (Fourier transform ion cyclotron resonance). Contour plots have been generated from the mixtures of O-linked oligosaccharides originated from bovine mucin and bile salt-stimulated lipase, a large glycoprotein enzyme.

Original languageEnglish
Pages (from-to)1684-1690
Number of pages7
JournalAnalytical Chemistry
Volume75
Issue number7
DOIs
StatePublished - Apr 1 2003

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