Abstract
Readily available triethylammonium 1-(2-oxoindolin-3-ylidene)-2- aroylethanethiolates are efficiently converted into a variety of fully substituted thiophene derivatives by copper(I)-catalyzed denitrogenative reactions with terminal alkynes and N-sulfonyl azides. This new reaction simultaneously installs C-N, C-S, and C-C bonds, allowing direct formation of highly functionalized thiophenes with a wide diversity in substituents in a one-pot manner. A plausible mechanism for the domino process is proposed.
| Original language | English |
|---|---|
| Pages (from-to) | 3656-3659 |
| Number of pages | 4 |
| Journal | Organic Letters |
| Volume | 16 |
| Issue number | 14 |
| DOIs | |
| State | Published - Jul 18 2014 |
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Jiang, B., Tu, X. J., Wang, X., Tu, S. J., & Li, G. (2014). Copper(I)-catalyzed multicomponent reaction providing a new access to fully substituted thiophene derivatives. Organic Letters, 16(14), 3656-3659. https://doi.org/10.1021/ol501404x