Copper(I)-catalyzed multicomponent reaction providing a new access to fully substituted thiophene derivatives

Bo Jiang, Xing Jun Tu, Xue Wang, Shu Jiang Tu, Guigen Li

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Readily available triethylammonium 1-(2-oxoindolin-3-ylidene)-2- aroylethanethiolates are efficiently converted into a variety of fully substituted thiophene derivatives by copper(I)-catalyzed denitrogenative reactions with terminal alkynes and N-sulfonyl azides. This new reaction simultaneously installs C-N, C-S, and C-C bonds, allowing direct formation of highly functionalized thiophenes with a wide diversity in substituents in a one-pot manner. A plausible mechanism for the domino process is proposed.

Original languageEnglish
Pages (from-to)3656-3659
Number of pages4
JournalOrganic Letters
Volume16
Issue number14
DOIs
StatePublished - Jul 18 2014

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