Copper-promoted site-selective acyloxylation of unactivated C(sp3)-H bonds

Xuesong Wu; Yan Zhao; Haibo Ge

doi:10.1002/asia.201402510

Copper-promoted site-selective acyloxylation of unactivated C(sp³)-H bonds

Xuesong Wu, Yan Zhao, Haibo Ge

Chemistry and Biochemistry

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

The site-selective acyloxylation of aliphatic amides was achieved via a copper-promoted C(sp³)-H bond functionalization process directed by a bidentate ligand. The reaction showed a great preference for activating C-H bonds of β-methyl groups over those of γ-methyl and unactivated methylene groups.

Original language	English
Pages (from-to)	2736-2739
Number of pages	4
Journal	Chemistry - An Asian Journal
Volume	9
Issue number	10
DOIs	https://doi.org/10.1002/asia.201402510
State	Published - Oct 1 2014

Keywords

Acyloxylation
C-H activation
Copper
Site-selective
Unactivated sp carbons

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10.1002/asia.201402510

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title = "Copper-promoted site-selective acyloxylation of unactivated C(sp3)-H bonds",

abstract = "The site-selective acyloxylation of aliphatic amides was achieved via a copper-promoted C(sp3)-H bond functionalization process directed by a bidentate ligand. The reaction showed a great preference for activating C-H bonds of β-methyl groups over those of γ-methyl and unactivated methylene groups.",

keywords = "Acyloxylation, C-H activation, Copper, Site-selective, Unactivated sp carbons",

author = "Xuesong Wu and Yan Zhao and Haibo Ge",

year = "2014",

month = oct,

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doi = "10.1002/asia.201402510",

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AU - Wu, Xuesong

AU - Zhao, Yan

AU - Ge, Haibo

PY - 2014/10/1

Y1 - 2014/10/1

N2 - The site-selective acyloxylation of aliphatic amides was achieved via a copper-promoted C(sp3)-H bond functionalization process directed by a bidentate ligand. The reaction showed a great preference for activating C-H bonds of β-methyl groups over those of γ-methyl and unactivated methylene groups.

AB - The site-selective acyloxylation of aliphatic amides was achieved via a copper-promoted C(sp3)-H bond functionalization process directed by a bidentate ligand. The reaction showed a great preference for activating C-H bonds of β-methyl groups over those of γ-methyl and unactivated methylene groups.

KW - Acyloxylation

KW - C-H activation

KW - Copper

KW - Site-selective

KW - Unactivated sp carbons

UR - http://www.scopus.com/inward/record.url?scp=84920710720&partnerID=8YFLogxK

U2 - 10.1002/asia.201402510

DO - 10.1002/asia.201402510

M3 - Article

SN - 1861-4728

VL - 9

SP - 2736

EP - 2739

JO - Chemistry - An Asian Journal

JF - Chemistry - An Asian Journal

IS - 10

ER -

Copper-promoted site-selective acyloxylation of unactivated C(sp³)-H bonds

Abstract

Keywords

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