Copper-Catalyzed Asymmetric Borylacylation of Styrene and Indene Derivatives

Zhen Yang, Peiyuan Li, Hongjian Lu, Guigen Li

Research output: Contribution to journalArticlepeer-review

Abstract

The enantioselective copper-catalyzed borylacylation of aryl olefins with acyl chlorides and bis-(pinacolato)diboron is reported. This three-component reaction involves an enantioselective syn-borylcupration of the aryl olefin, followed by a nucleophilic attack on the acyl chloride. This reaction proceeds with a 2 mol % catalyst loading and is generally completed within 30 min at room temperature. Because the boron moiety can be converted into versatile functional groups and the carbonyl group is a ubiquitous functional group, the resulting chiral β-borylated ketones are versatile intermediates in organic synthesis.

Original languageEnglish
Pages (from-to)4616-4624
Number of pages9
JournalJournal of Organic Chemistry
Volume86
Issue number6
DOIs
StatePublished - Mar 19 2021

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