Abstract
The enantioselective copper-catalyzed borylacylation of aryl olefins with acyl chlorides and bis-(pinacolato)diboron is reported. This three-component reaction involves an enantioselective syn-borylcupration of the aryl olefin, followed by a nucleophilic attack on the acyl chloride. This reaction proceeds with a 2 mol % catalyst loading and is generally completed within 30 min at room temperature. Because the boron moiety can be converted into versatile functional groups and the carbonyl group is a ubiquitous functional group, the resulting chiral β-borylated ketones are versatile intermediates in organic synthesis.
Original language | English |
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Pages (from-to) | 4616-4624 |
Number of pages | 9 |
Journal | Journal of Organic Chemistry |
Volume | 86 |
Issue number | 6 |
DOIs | |
State | Published - Mar 19 2021 |