Copper-catalyzed aminohalogenation using the 2-NsNCl2/2-NsNHNa combination as the nitrogen and halogen sources for the synthesis of anti-alkyl 3-chloro-2-(o-nitrobenzenesulfonamido)-3-arylpropionates

Guigen Li, Han Xun Wei, Sun Hee Kim

Research output: Contribution to journalArticlepeer-review

93 Scopus citations

Abstract

(equation presented) New regio- and stereoselective aminohalogenation of cinnamic esters has been developed using the combination of 2-NsNCl2/2-NsNHNa as the nitrogen and chlorine sources and copper(I) triflate as the catalyst. The new procedure provides an efficient synthesis of anti-alkyl 3-chloro2-(o-nitrobenzenesulfonamido)-3-phenylpropionate derivatives. Nine examples are presented with good yields (62-82%) and stereoselectivity ((5:1)-(30:1)).

Original languageEnglish
Pages (from-to)2249-2252
Number of pages4
JournalOrganic Letters
Volume2
Issue number15
DOIs
StatePublished - Jul 27 2000

Fingerprint Dive into the research topics of 'Copper-catalyzed aminohalogenation using the 2-NsNCl<sub>2</sub>/2-NsNHNa combination as the nitrogen and halogen sources for the synthesis of anti-alkyl 3-chloro-2-(o-nitrobenzenesulfonamido)-3-arylpropionates'. Together they form a unique fingerprint.

Cite this