Abstract
An aerobic activity: The title reaction proceeds through an oxidation/cyclization/aromatization sequence under an atmosphere of O 2 (see scheme; DBU=1,8-diazabicyclo[5.4.0]undec-7-ene, DCE=1,2-dichloroethane, DMS=dimethylsulfide). This coupling reaction is the first to proceed via an iminium intermediate for a C sp 3-H bond- functionalization process, and provides an environmentally friendly and atom-efficient access to substituted pyrazoles.
Original language | English |
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Pages (from-to) | 2559-2563 |
Number of pages | 5 |
Journal | Angewandte Chemie - International Edition |
Volume | 52 |
Issue number | 9 |
DOIs | |
State | Published - Feb 25 2013 |
Keywords
- C-H activation
- copper
- cyclization
- heterocycles
- oxygen