Abstract
O2 leading the way: The title reaction proceeds through an oxidation/cyclization sequence, thus representing the first copper-catalyzed coupling reaction of hydrazones through a C sp 3-H bond functionalization process (see scheme; DMF=N,N'-dimethylformamide, Py=pyridine). The method provides an environmentally friendly and atom-efficient approach to biologically active cinnoline derivatives.
Original language | English |
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Pages (from-to) | 8318-8321 |
Number of pages | 4 |
Journal | Angewandte Chemie - International Edition |
Volume | 51 |
Issue number | 33 |
DOIs | |
State | Published - Aug 13 2012 |
Keywords
- C-C coupling
- copper
- heterocycles
- oxygen
- synthetic methods